HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1,...

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Autores principales:	Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
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spelling	oai:doaj.org-article:cf78ebbf481d47ad9ecf5de60d0357a82021-12-02T14:41:58ZHSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells10.1038/ncomms156482041-1723https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a82017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15648https://doaj.org/toc/2041-1723Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells.Lauren B. Kinner-BibeauAbigail L. SedlacekMichelle N. MessmerSimon C. WatkinsRobert J. BinderNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren B. Kinner-Bibeau Abigail L. Sedlacek Michelle N. Messmer Simon C. Watkins Robert J. Binder HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
description	Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells.
format	article
author	Lauren B. Kinner-Bibeau Abigail L. Sedlacek Michelle N. Messmer Simon C. Watkins Robert J. Binder
author_facet	Lauren B. Kinner-Bibeau Abigail L. Sedlacek Michelle N. Messmer Simon C. Watkins Robert J. Binder
author_sort	Lauren B. Kinner-Bibeau
title	HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
title_short	HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
title_full	HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
title_fullStr	HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
title_full_unstemmed	HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells
title_sort	hsps drive dichotomous t-cell immune responses via dna methylome remodelling in antigen presenting cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
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HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

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