HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1,...

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Autores principales: Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
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