AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2

3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing- or cancer cells.

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Auteurs principaux:	Acong Yang, Tie-Juan Shao, Xavier Bofill-De Ros, Chuanjiang Lian, Patricia Villanueva, Lisheng Dai, Shuo Gu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f70
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spelling	oai:doaj.org-article:cf79b8e7987b4e57af1d8a30458a8f702021-12-02T17:51:12ZAGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L210.1038/s41467-020-16533-w2041-1723https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f702020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16533-whttps://doaj.org/toc/2041-17233′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing- or cancer cells.Acong YangTie-Juan ShaoXavier Bofill-De RosChuanjiang LianPatricia VillanuevaLisheng DaiShuo GuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Acong Yang Tie-Juan Shao Xavier Bofill-De Ros Chuanjiang Lian Patricia Villanueva Lisheng Dai Shuo Gu AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
description	3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing- or cancer cells.
format	article
author	Acong Yang Tie-Juan Shao Xavier Bofill-De Ros Chuanjiang Lian Patricia Villanueva Lisheng Dai Shuo Gu
author_facet	Acong Yang Tie-Juan Shao Xavier Bofill-De Ros Chuanjiang Lian Patricia Villanueva Lisheng Dai Shuo Gu
author_sort	Acong Yang
title	AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
title_short	AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
title_full	AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
title_fullStr	AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
title_full_unstemmed	AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
title_sort	ago-bound mature mirnas are oligouridylated by tuts and subsequently degraded by dis3l2
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cf79b8e7987b4e57af1d8a30458a8f70
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AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2

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