Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in...

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Autores principales: Bénedith Oben, Guy Froyen, Kylee H. Maclachlan, Daniel Leongamornlert, Federico Abascal, Binbin Zheng-Lin, Venkata Yellapantula, Andriy Derkach, Ellen Geerdens, Benjamin T. Diamond, Ingrid Arijs, Brigitte Maes, Kimberly Vanhees, Malin Hultcrantz, Elisabet E. Manasanch, Dickran Kazandjian, Alexander Lesokhin, Ahmet Dogan, Yanming Zhang, Aneta Mikulasova, Brian Walker, Gareth Morgan, Peter J. Campbell, Ola Landgren, Jean-Luc Rummens, Niccolò Bolli, Francesco Maura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cf7b932cecac4fc1b4e380aa66de4cb0
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spelling oai:doaj.org-article:cf7b932cecac4fc1b4e380aa66de4cb02021-12-02T17:04:30ZWhole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities10.1038/s41467-021-22140-02041-1723https://doaj.org/article/cf7b932cecac4fc1b4e380aa66de4cb02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22140-0https://doaj.org/toc/2041-1723The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in the patient’s life.Bénedith ObenGuy FroyenKylee H. MaclachlanDaniel LeongamornlertFederico AbascalBinbin Zheng-LinVenkata YellapantulaAndriy DerkachEllen GeerdensBenjamin T. DiamondIngrid ArijsBrigitte MaesKimberly VanheesMalin HultcrantzElisabet E. ManasanchDickran KazandjianAlexander LesokhinAhmet DoganYanming ZhangAneta MikulasovaBrian WalkerGareth MorganPeter J. CampbellOla LandgrenJean-Luc RummensNiccolò BolliFrancesco MauraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bénedith Oben
Guy Froyen
Kylee H. Maclachlan
Daniel Leongamornlert
Federico Abascal
Binbin Zheng-Lin
Venkata Yellapantula
Andriy Derkach
Ellen Geerdens
Benjamin T. Diamond
Ingrid Arijs
Brigitte Maes
Kimberly Vanhees
Malin Hultcrantz
Elisabet E. Manasanch
Dickran Kazandjian
Alexander Lesokhin
Ahmet Dogan
Yanming Zhang
Aneta Mikulasova
Brian Walker
Gareth Morgan
Peter J. Campbell
Ola Landgren
Jean-Luc Rummens
Niccolò Bolli
Francesco Maura
Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
description The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in the patient’s life.
format article
author Bénedith Oben
Guy Froyen
Kylee H. Maclachlan
Daniel Leongamornlert
Federico Abascal
Binbin Zheng-Lin
Venkata Yellapantula
Andriy Derkach
Ellen Geerdens
Benjamin T. Diamond
Ingrid Arijs
Brigitte Maes
Kimberly Vanhees
Malin Hultcrantz
Elisabet E. Manasanch
Dickran Kazandjian
Alexander Lesokhin
Ahmet Dogan
Yanming Zhang
Aneta Mikulasova
Brian Walker
Gareth Morgan
Peter J. Campbell
Ola Landgren
Jean-Luc Rummens
Niccolò Bolli
Francesco Maura
author_facet Bénedith Oben
Guy Froyen
Kylee H. Maclachlan
Daniel Leongamornlert
Federico Abascal
Binbin Zheng-Lin
Venkata Yellapantula
Andriy Derkach
Ellen Geerdens
Benjamin T. Diamond
Ingrid Arijs
Brigitte Maes
Kimberly Vanhees
Malin Hultcrantz
Elisabet E. Manasanch
Dickran Kazandjian
Alexander Lesokhin
Ahmet Dogan
Yanming Zhang
Aneta Mikulasova
Brian Walker
Gareth Morgan
Peter J. Campbell
Ola Landgren
Jean-Luc Rummens
Niccolò Bolli
Francesco Maura
author_sort Bénedith Oben
title Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
title_short Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
title_full Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
title_fullStr Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
title_full_unstemmed Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
title_sort whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cf7b932cecac4fc1b4e380aa66de4cb0
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