Gene isoforms as expression-based biomarkers predictive of drug response in vitro

Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response, and show them to frequently be strong predictors.

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Autores principales:	Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece89
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spelling	oai:doaj.org-article:cf7eac9f211140b5ac75f6d34ebece892021-12-02T15:38:35ZGene isoforms as expression-based biomarkers predictive of drug response in vitro10.1038/s41467-017-01153-82041-1723https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece892017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01153-8https://doaj.org/toc/2041-1723Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response, and show them to frequently be strong predictors.Zhaleh SafikhaniPetr SmirnovKelsie L. ThuJennifer SilvesterNehme El-HachemRene QuevedoMathieu LupienTak W. MakDavid CesconBenjamin Haibe-KainsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaleh Safikhani Petr Smirnov Kelsie L. Thu Jennifer Silvester Nehme El-Hachem Rene Quevedo Mathieu Lupien Tak W. Mak David Cescon Benjamin Haibe-Kains Gene isoforms as expression-based biomarkers predictive of drug response in vitro
description	Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response, and show them to frequently be strong predictors.
format	article
author	Zhaleh Safikhani Petr Smirnov Kelsie L. Thu Jennifer Silvester Nehme El-Hachem Rene Quevedo Mathieu Lupien Tak W. Mak David Cescon Benjamin Haibe-Kains
author_facet	Zhaleh Safikhani Petr Smirnov Kelsie L. Thu Jennifer Silvester Nehme El-Hachem Rene Quevedo Mathieu Lupien Tak W. Mak David Cescon Benjamin Haibe-Kains
author_sort	Zhaleh Safikhani
title	Gene isoforms as expression-based biomarkers predictive of drug response in vitro
title_short	Gene isoforms as expression-based biomarkers predictive of drug response in vitro
title_full	Gene isoforms as expression-based biomarkers predictive of drug response in vitro
title_fullStr	Gene isoforms as expression-based biomarkers predictive of drug response in vitro
title_full_unstemmed	Gene isoforms as expression-based biomarkers predictive of drug response in vitro
title_sort	gene isoforms as expression-based biomarkers predictive of drug response in vitro
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece89
work_keys_str_mv	AT zhalehsafikhani geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT petrsmirnov geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT kelsielthu geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT jennifersilvester geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT nehmeelhachem geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT renequevedo geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT mathieulupien geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT takwmak geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT davidcescon geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro AT benjaminhaibekains geneisoformsasexpressionbasedbiomarkerspredictiveofdrugresponseinvitro
_version_	1718386142014865408

Gene isoforms as expression-based biomarkers predictive of drug response in vitro

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