Gene isoforms as expression-based biomarkers predictive of drug response in vitro

Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response, and show them to frequently be strong predictors.

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Autores principales: Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece89
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