Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy.

Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy.

<h4>Objectives</h4>Systemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of critically ill patients. To test t...

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Main Authors: Claudia Langhans, Steffen Weber-Carstens, Franziska Schmidt, Jida Hamati, Melanie Kny, Xiaoxi Zhu, Tobias Wollersheim, Susanne Koch, Martin Krebs, Herbert Schulz, Doerte Lodka, Kathrin Saar, Siegfried Labeit, Claudia Spies, Norbert Hubner, Joachim Spranger, Simone Spuler, Michael Boschmann, Gunnar Dittmar, Gillian Butler-Browne, Vincent Mouly, Jens Fielitz
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/cf7eaf06922144069334d2915c85c5a8
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