Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

Trophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.

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Autores principales: Jia Liu, Shengnan Hao, Xi Chen, Hui Zhao, Lutao Du, Hanxiao Ren, Chuanxin Wang, Haiting Mao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cf7fe7edd61849c6b26a95d6606caef6
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spelling oai:doaj.org-article:cf7fe7edd61849c6b26a95d6606caef62021-12-02T17:01:26ZHuman placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion10.1038/s41467-019-12484-z2041-1723https://doaj.org/article/cf7fe7edd61849c6b26a95d6606caef62019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12484-zhttps://doaj.org/toc/2041-1723Trophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.Jia LiuShengnan HaoXi ChenHui ZhaoLutao DuHanxiao RenChuanxin WangHaiting MaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
description Trophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.
format article
author Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
author_facet Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
author_sort Jia Liu
title Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_short Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_full Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_fullStr Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_full_unstemmed Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_sort human placental trophoblast cells contribute to maternal–fetal tolerance through expressing il-35 and mediating itr35 conversion
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/cf7fe7edd61849c6b26a95d6606caef6
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AT shengnanhao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT xichen humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT huizhao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT lutaodu humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT hanxiaoren humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT chuanxinwang humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT haitingmao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
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