Genetic characterization of nodular worm infections in Asian Apes

Abstract Parasitic nematodes of Oesophagostomum spp., commonly known, as 'nodular worms' are emerging as the most widely distributed and prevalent zoonotic nematodes. Oesophagostomum infections are well documented in African non-human primates; however, the taxonomy, distribution and trans...

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Autores principales:	Erhan Yalcindag, Peter Stuart, Hideo Hasegawa, Adrian Streit, Jana Doležalová, Helen Morrogh-Bernard, Susan M. Cheyne, Wisnu Nurcahyo, Ivona Foitová
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf81327c70f847dc87b643297c7030ca
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spelling	oai:doaj.org-article:cf81327c70f847dc87b643297c7030ca2021-12-02T14:23:32ZGenetic characterization of nodular worm infections in Asian Apes10.1038/s41598-021-86518-22045-2322https://doaj.org/article/cf81327c70f847dc87b643297c7030ca2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86518-2https://doaj.org/toc/2045-2322Abstract Parasitic nematodes of Oesophagostomum spp., commonly known, as 'nodular worms' are emerging as the most widely distributed and prevalent zoonotic nematodes. Oesophagostomum infections are well documented in African non-human primates; however, the taxonomy, distribution and transmission of Oesophagostomum in Asian non-human primates are not adequately studied. To better understand which Oesophagostomum species infect Asian non-human primates and determine their phylogeny we analysed 55 faecal samples from 50 orangutan and 5 gibbon individuals from Borneo and Sumatra. Both microscopy and molecular results revealed that semi-wild animals had higher Oesophagostomum infection prevalence than free ranging animals. Based on sequence genotyping analysis targeting the Internal transcribed spacer 2 of rDNA, we report for the first time the presence of O. aculeatum in Sumatran apes. Population genetic analysis shows that there is significant genetic differentiation between Bornean and Sumatran O. aculeatum populations. Our results clearly reveal that O. aculeatum in free-ranging animals have a higher genetic variation than those in semi-wild animals, demonstrating that O. aculeatum is circulating naturally in wildlife and zoonotic transmission is possible. Further studies should be conducted to better understand the epidemiology and dynamics of Oesophagostomum transmission between humans, non-human primates and other wild species and livestock in Southeast Asia.Erhan YalcindagPeter StuartHideo HasegawaAdrian StreitJana DoležalováHelen Morrogh-BernardSusan M. CheyneWisnu NurcahyoIvona FoitováNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erhan Yalcindag Peter Stuart Hideo Hasegawa Adrian Streit Jana Doležalová Helen Morrogh-Bernard Susan M. Cheyne Wisnu Nurcahyo Ivona Foitová Genetic characterization of nodular worm infections in Asian Apes
description	Abstract Parasitic nematodes of Oesophagostomum spp., commonly known, as 'nodular worms' are emerging as the most widely distributed and prevalent zoonotic nematodes. Oesophagostomum infections are well documented in African non-human primates; however, the taxonomy, distribution and transmission of Oesophagostomum in Asian non-human primates are not adequately studied. To better understand which Oesophagostomum species infect Asian non-human primates and determine their phylogeny we analysed 55 faecal samples from 50 orangutan and 5 gibbon individuals from Borneo and Sumatra. Both microscopy and molecular results revealed that semi-wild animals had higher Oesophagostomum infection prevalence than free ranging animals. Based on sequence genotyping analysis targeting the Internal transcribed spacer 2 of rDNA, we report for the first time the presence of O. aculeatum in Sumatran apes. Population genetic analysis shows that there is significant genetic differentiation between Bornean and Sumatran O. aculeatum populations. Our results clearly reveal that O. aculeatum in free-ranging animals have a higher genetic variation than those in semi-wild animals, demonstrating that O. aculeatum is circulating naturally in wildlife and zoonotic transmission is possible. Further studies should be conducted to better understand the epidemiology and dynamics of Oesophagostomum transmission between humans, non-human primates and other wild species and livestock in Southeast Asia.
format	article
author	Erhan Yalcindag Peter Stuart Hideo Hasegawa Adrian Streit Jana Doležalová Helen Morrogh-Bernard Susan M. Cheyne Wisnu Nurcahyo Ivona Foitová
author_facet	Erhan Yalcindag Peter Stuart Hideo Hasegawa Adrian Streit Jana Doležalová Helen Morrogh-Bernard Susan M. Cheyne Wisnu Nurcahyo Ivona Foitová
author_sort	Erhan Yalcindag
title	Genetic characterization of nodular worm infections in Asian Apes
title_short	Genetic characterization of nodular worm infections in Asian Apes
title_full	Genetic characterization of nodular worm infections in Asian Apes
title_fullStr	Genetic characterization of nodular worm infections in Asian Apes
title_full_unstemmed	Genetic characterization of nodular worm infections in Asian Apes
title_sort	genetic characterization of nodular worm infections in asian apes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf81327c70f847dc87b643297c7030ca
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Genetic characterization of nodular worm infections in Asian Apes

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