PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION

Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation of the immune system, etc. In the pre...

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Autores principales:	V. V. Zarubaev, A. V. Slita, I. N. Lavrentyeva, V. S. Smirnov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	vitamin c ascorbic acid influenza antivirals anti-inflammatory activity antioxidant activity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cf83074e865849ccafc7aec0360ca978
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spelling	oai:doaj.org-article:cf83074e865849ccafc7aec0360ca9782021-11-22T07:09:48ZPROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION2220-76192313-739810.15789/2220-7619-2017-4-319-326https://doaj.org/article/cf83074e865849ccafc7aec0360ca9782018-01-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/588https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation of the immune system, etc. In the present review the activities of AA are considered that provide its protective effect at influenza infection. This effect can be result of direct virus-inhibiting activity of AA as well as of anti-inflammatory and antioxidant properties. Oxidative stress during influenza infection leads to nonspecific damage of the pulmonary tissue and subsequent inflammation of the lungs. The antioxidant activity of AA results in alleviation of infection due to suppression of tissue damage as well as in inhibition of reactive oxygen species-mediated signal transduction and regulatory reactions. After oxidation by ROS, AA is converted to dehydroascorbic acid (DAA) and inhibits the key enzymes of NF-κB pathway, such as kinases IKKα and IKKβ. AA itself blocks the activity of another component of the NF-kB pathway, kinase IKKβ(SS/EE), whose activity is directed to the phosphorylation of the factor IκBα. As a result, activation of NF-κB and its transport to the nucleus does not occur. Thus, AA performs a dual function: first, it neutralizes free radicals, preventing them from activating NF-κB, and secondly, the product of its oxidation, DAA, further blocks the activation of this pathway. In addition, in some cases AA results in the decrease in the infectious activity of influenza virus that is not due to the antioxidant activity of AA, but to direct virus-inhibiting activity. Taken together, the presented data suggests that the use of drugs with antiviral and antioxidant activity, as a combination of individual drugs or, as in the case of AA, as a single drug with complex activity, for treatment of influenza has advantages over the etiotropic drug monotherapy scheme.V. V. ZarubaevA. V. SlitaI. N. LavrentyevaV. S. SmirnovSankt-Peterburg : NIIÈM imeni Pasteraarticlevitamin cascorbic acidinfluenzaantiviralsanti-inflammatory activityantioxidant activityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 4, Pp 319-326 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	vitamin c ascorbic acid influenza antivirals anti-inflammatory activity antioxidant activity Infectious and parasitic diseases RC109-216
spellingShingle	vitamin c ascorbic acid influenza antivirals anti-inflammatory activity antioxidant activity Infectious and parasitic diseases RC109-216 V. V. Zarubaev A. V. Slita I. N. Lavrentyeva V. S. Smirnov PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
description	Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation of the immune system, etc. In the present review the activities of AA are considered that provide its protective effect at influenza infection. This effect can be result of direct virus-inhibiting activity of AA as well as of anti-inflammatory and antioxidant properties. Oxidative stress during influenza infection leads to nonspecific damage of the pulmonary tissue and subsequent inflammation of the lungs. The antioxidant activity of AA results in alleviation of infection due to suppression of tissue damage as well as in inhibition of reactive oxygen species-mediated signal transduction and regulatory reactions. After oxidation by ROS, AA is converted to dehydroascorbic acid (DAA) and inhibits the key enzymes of NF-κB pathway, such as kinases IKKα and IKKβ. AA itself blocks the activity of another component of the NF-kB pathway, kinase IKKβ(SS/EE), whose activity is directed to the phosphorylation of the factor IκBα. As a result, activation of NF-κB and its transport to the nucleus does not occur. Thus, AA performs a dual function: first, it neutralizes free radicals, preventing them from activating NF-κB, and secondly, the product of its oxidation, DAA, further blocks the activation of this pathway. In addition, in some cases AA results in the decrease in the infectious activity of influenza virus that is not due to the antioxidant activity of AA, but to direct virus-inhibiting activity. Taken together, the presented data suggests that the use of drugs with antiviral and antioxidant activity, as a combination of individual drugs or, as in the case of AA, as a single drug with complex activity, for treatment of influenza has advantages over the etiotropic drug monotherapy scheme.
format	article
author	V. V. Zarubaev A. V. Slita I. N. Lavrentyeva V. S. Smirnov
author_facet	V. V. Zarubaev A. V. Slita I. N. Lavrentyeva V. S. Smirnov
author_sort	V. V. Zarubaev
title	PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
title_short	PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
title_full	PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
title_fullStr	PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
title_full_unstemmed	PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION
title_sort	protective activity of ascorbic acid at influenza infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/cf83074e865849ccafc7aec0360ca978
work_keys_str_mv	AT vvzarubaev protectiveactivityofascorbicacidatinfluenzainfection AT avslita protectiveactivityofascorbicacidatinfluenzainfection AT inlavrentyeva protectiveactivityofascorbicacidatinfluenzainfection AT vssmirnov protectiveactivityofascorbicacidatinfluenzainfection
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PROTECTIVE ACTIVITY OF ASCORBIC ACID AT INFLUENZA INFECTION

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