Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols.

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Autores principales:	Magali de Bruyn, Christine Breynaert, Ingrid Arijs, Gert De Hertogh, Karel Geboes, Greet Thijs, Gianluca Matteoli, Jialiang Hu, Jo Van Damme, Bernd Arnold, Marc Ferrante, Séverine Vermeire, Gert Van Assche, Ghislain Opdenakker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf83337903164ea1a97bfb338b28091a
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spelling	oai:doaj.org-article:cf83337903164ea1a97bfb338b28091a2021-12-02T14:42:24ZInhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease10.1038/ncomms153842041-1723https://doaj.org/article/cf83337903164ea1a97bfb338b28091a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15384https://doaj.org/toc/2041-1723Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols.Magali de BruynChristine BreynaertIngrid ArijsGert De HertoghKarel GeboesGreet ThijsGianluca MatteoliJialiang HuJo Van DammeBernd ArnoldMarc FerranteSéverine VermeireGert Van AsscheGhislain OpdenakkerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magali de Bruyn Christine Breynaert Ingrid Arijs Gert De Hertogh Karel Geboes Greet Thijs Gianluca Matteoli Jialiang Hu Jo Van Damme Bernd Arnold Marc Ferrante Séverine Vermeire Gert Van Assche Ghislain Opdenakker Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
description	Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols.
format	article
author	Magali de Bruyn Christine Breynaert Ingrid Arijs Gert De Hertogh Karel Geboes Greet Thijs Gianluca Matteoli Jialiang Hu Jo Van Damme Bernd Arnold Marc Ferrante Séverine Vermeire Gert Van Assche Ghislain Opdenakker
author_facet	Magali de Bruyn Christine Breynaert Ingrid Arijs Gert De Hertogh Karel Geboes Greet Thijs Gianluca Matteoli Jialiang Hu Jo Van Damme Bernd Arnold Marc Ferrante Séverine Vermeire Gert Van Assche Ghislain Opdenakker
author_sort	Magali de Bruyn
title	Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
title_short	Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
title_full	Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
title_fullStr	Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
title_full_unstemmed	Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
title_sort	inhibition of gelatinase b/mmp-9 does not attenuate colitis in murine models of inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cf83337903164ea1a97bfb338b28091a
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Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

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