Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

Context Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor most commonly occurring in deep intramuscular plane of lower extremities of adolescents and young adults. It is a highly vascular, slow growing tumor with malignant potential having lung as the most common site of metastases at th...

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Autores principales:	Malvika Gulati, Abhenil Mittal, Adarsh Barwad, Rambha Pandey, Sameer Rastogi, Ekta Dhamija
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	alveolar soft part sarcoma soft tissue sarcoma imaging feeding vessels metastatic disease Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/cf83dea8b60644cdb03be5536c3637c7
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spelling	oai:doaj.org-article:cf83dea8b60644cdb03be5536c3637c72021-11-13T23:32:30ZImaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients0971-30261998-380810.1055/s-0041-1735501https://doaj.org/article/cf83dea8b60644cdb03be5536c3637c72021-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735501https://doaj.org/toc/0971-3026https://doaj.org/toc/1998-3808Context Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor most commonly occurring in deep intramuscular plane of lower extremities of adolescents and young adults. It is a highly vascular, slow growing tumor with malignant potential having lung as the most common site of metastases at the time of presentation. Aims The aim is to review the imaging findings of ASPS and determine characteristic imaging features of this rare tumor. Materials and Methods Sixteen patients having histopathological diagnosis and preoperative imaging of ASPS attending the dedicated sarcoma clinic at our institute were included in the study. The demographic, clinical, and imaging data were retrieved from the case records and then evaluated for characteristic imaging features which may raise suspicion of ASPS. Results The patients ranged from 3 to 72 years of age and with a slight male preponderance. Of the eight CECTs evaluated, 62.5% tumors showed well-defined lobulated margins, 87.5% cases showed intense enhancement with presence of feeder vessels. On CEMRI of 10 patients, 70% had well circumscribed lobulated margins with intense enhancement and tortuous flow voids in most of them. All cases showed T2 hyperintense signal. Fourteen of 16 (87.5%) patients had metastatic disease with lung as the most common site (92.8%). Conclusion ASPS is a rare soft tissue sarcoma seen in children and young adults. Imaging may mimic a vascular malformation due to the presence of tortuous feeders. Misdiagnosis at an early stage may lead to later metastatic presentation of the disease, thus emphasizing the need to suspect it on imaging.Malvika GulatiAbhenil MittalAdarsh BarwadRambha PandeySameer RastogiEkta DhamijaThieme Medical and Scientific Publishers Pvt. Ltd.articlealveolar soft part sarcomasoft tissue sarcomaimagingfeeding vesselsmetastatic diseaseMedical physics. Medical radiology. Nuclear medicineR895-920ENIndian Journal of Radiology and Imaging, Vol 31, Iss 03, Pp 573-581 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alveolar soft part sarcoma soft tissue sarcoma imaging feeding vessels metastatic disease Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	alveolar soft part sarcoma soft tissue sarcoma imaging feeding vessels metastatic disease Medical physics. Medical radiology. Nuclear medicine R895-920 Malvika Gulati Abhenil Mittal Adarsh Barwad Rambha Pandey Sameer Rastogi Ekta Dhamija Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
description	Context Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor most commonly occurring in deep intramuscular plane of lower extremities of adolescents and young adults. It is a highly vascular, slow growing tumor with malignant potential having lung as the most common site of metastases at the time of presentation. Aims The aim is to review the imaging findings of ASPS and determine characteristic imaging features of this rare tumor. Materials and Methods Sixteen patients having histopathological diagnosis and preoperative imaging of ASPS attending the dedicated sarcoma clinic at our institute were included in the study. The demographic, clinical, and imaging data were retrieved from the case records and then evaluated for characteristic imaging features which may raise suspicion of ASPS. Results The patients ranged from 3 to 72 years of age and with a slight male preponderance. Of the eight CECTs evaluated, 62.5% tumors showed well-defined lobulated margins, 87.5% cases showed intense enhancement with presence of feeder vessels. On CEMRI of 10 patients, 70% had well circumscribed lobulated margins with intense enhancement and tortuous flow voids in most of them. All cases showed T2 hyperintense signal. Fourteen of 16 (87.5%) patients had metastatic disease with lung as the most common site (92.8%). Conclusion ASPS is a rare soft tissue sarcoma seen in children and young adults. Imaging may mimic a vascular malformation due to the presence of tortuous feeders. Misdiagnosis at an early stage may lead to later metastatic presentation of the disease, thus emphasizing the need to suspect it on imaging.
format	article
author	Malvika Gulati Abhenil Mittal Adarsh Barwad Rambha Pandey Sameer Rastogi Ekta Dhamija
author_facet	Malvika Gulati Abhenil Mittal Adarsh Barwad Rambha Pandey Sameer Rastogi Ekta Dhamija
author_sort	Malvika Gulati
title	Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
title_short	Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
title_full	Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
title_fullStr	Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
title_full_unstemmed	Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients
title_sort	imaging and pathological features of alveolar soft part sarcoma: analysis of 16 patients
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/cf83dea8b60644cdb03be5536c3637c7
work_keys_str_mv	AT malvikagulati imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients AT abhenilmittal imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients AT adarshbarwad imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients AT rambhapandey imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients AT sameerrastogi imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients AT ektadhamija imagingandpathologicalfeaturesofalveolarsoftpartsarcomaanalysisof16patients
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Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

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