Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
Multidrug transporters possess several drug binding sites. Here the authors describe a transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB.
Enregistré dans:
Auteurs principaux: | Martijn Zwama, Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/cf87738eec424a5bb6b49a27e8fde79a |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
par: Kunihiko Nishino, et autres
Publié: (2021) -
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
par: Elizabeth M. Grimsey, et autres
Publié: (2020) -
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
par: Eamonn Reading, et autres
Publié: (2020) -
Allosteric drug transport mechanism of multidrug transporter AcrB
par: Heng-Keat Tam, et autres
Publié: (2021) -
Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
par: Christine Oswald, et autres
Publié: (2016)