Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

Abstract This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients w...

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Autores principales:	Hiroshi Saito, Tatsuya Ishikawa, Jun Tanabe, Shinya Kobayashi, Junta Moroi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cf883f7a83aa4176ab36a59a3adf333c
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spelling	oai:doaj.org-article:cf883f7a83aa4176ab36a59a3adf333c2021-12-02T15:08:39ZBedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease10.1038/s41598-018-19668-52045-2322https://doaj.org/article/cf883f7a83aa4176ab36a59a3adf333c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19668-5https://doaj.org/toc/2045-2322Abstract This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15O-labeled gas. The BFI ratio showed the best correlation with the rCBF ratio among these parameters (r = 0.618; P = 0.0004), and the RT ratio showed the best correlation with the rOEF ratio (r = 0.593; P = 0.0007). The patients were further divided into reduced rCBF or elevated rOEF groups, and the analysis revealed significant related differences. The present results advance the measurement of ICG kinetics using NIRS as a useful tool for the detection of severely impaired perfusion with reduced rCBF or elevated rOEF. This method may be applicable as a monitoring tool for patients with acute ischemic stroke.Hiroshi SaitoTatsuya IshikawaJun TanabeShinya KobayashiJunta MoroiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroshi Saito Tatsuya Ishikawa Jun Tanabe Shinya Kobayashi Junta Moroi Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
description	Abstract This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15O-labeled gas. The BFI ratio showed the best correlation with the rCBF ratio among these parameters (r = 0.618; P = 0.0004), and the RT ratio showed the best correlation with the rOEF ratio (r = 0.593; P = 0.0007). The patients were further divided into reduced rCBF or elevated rOEF groups, and the analysis revealed significant related differences. The present results advance the measurement of ICG kinetics using NIRS as a useful tool for the detection of severely impaired perfusion with reduced rCBF or elevated rOEF. This method may be applicable as a monitoring tool for patients with acute ischemic stroke.
format	article
author	Hiroshi Saito Tatsuya Ishikawa Jun Tanabe Shinya Kobayashi Junta Moroi
author_facet	Hiroshi Saito Tatsuya Ishikawa Jun Tanabe Shinya Kobayashi Junta Moroi
author_sort	Hiroshi Saito
title	Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
title_short	Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
title_full	Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
title_fullStr	Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
title_full_unstemmed	Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
title_sort	bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cf883f7a83aa4176ab36a59a3adf333c
work_keys_str_mv	AT hiroshisaito bedsideassessmentofregionalcerebralperfusionusingnearinfraredspectroscopyandindocyaninegreeninpatientswithatheroscleroticocclusivedisease AT tatsuyaishikawa bedsideassessmentofregionalcerebralperfusionusingnearinfraredspectroscopyandindocyaninegreeninpatientswithatheroscleroticocclusivedisease AT juntanabe bedsideassessmentofregionalcerebralperfusionusingnearinfraredspectroscopyandindocyaninegreeninpatientswithatheroscleroticocclusivedisease AT shinyakobayashi bedsideassessmentofregionalcerebralperfusionusingnearinfraredspectroscopyandindocyaninegreeninpatientswithatheroscleroticocclusivedisease AT juntamoroi bedsideassessmentofregionalcerebralperfusionusingnearinfraredspectroscopyandindocyaninegreeninpatientswithatheroscleroticocclusivedisease
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Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

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