Extent of myosin penetration within the actin cortex regulates cell surface mechanics

Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with c...

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Autores principales:	Binh An Truong Quang, Ruby Peters, Davide A. D. Cassani, Priyamvada Chugh, Andrew G. Clark, Meghan Agnew, Guillaume Charras, Ewa K. Paluch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf89e257b5b749cea33f19cc411e938e
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spelling	oai:doaj.org-article:cf89e257b5b749cea33f19cc411e938e2021-11-14T12:34:20ZExtent of myosin penetration within the actin cortex regulates cell surface mechanics10.1038/s41467-021-26611-22041-1723https://doaj.org/article/cf89e257b5b749cea33f19cc411e938e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26611-2https://doaj.org/toc/2041-1723Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with cortical actin.Binh An Truong QuangRuby PetersDavide A. D. CassaniPriyamvada ChughAndrew G. ClarkMeghan AgnewGuillaume CharrasEwa K. PaluchNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch Extent of myosin penetration within the actin cortex regulates cell surface mechanics
description	Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with cortical actin.
format	article
author	Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch
author_facet	Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch
author_sort	Binh An Truong Quang
title	Extent of myosin penetration within the actin cortex regulates cell surface mechanics
title_short	Extent of myosin penetration within the actin cortex regulates cell surface mechanics
title_full	Extent of myosin penetration within the actin cortex regulates cell surface mechanics
title_fullStr	Extent of myosin penetration within the actin cortex regulates cell surface mechanics
title_full_unstemmed	Extent of myosin penetration within the actin cortex regulates cell surface mechanics
title_sort	extent of myosin penetration within the actin cortex regulates cell surface mechanics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cf89e257b5b749cea33f19cc411e938e
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Extent of myosin penetration within the actin cortex regulates cell surface mechanics

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