Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy

Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 2...

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Autores principales:	Daniela Loconsole, Francesca Centrone, Caterina Morcavallo, Silvia Campanella, Marisa Accogli, Anna Sallustio, Davide Peccarisi, Angela Stufano, Piero Lovreglio, Maria Chironna
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 Delta variant SARS-CoV-2 Alpha variant COVID-19 vaccine surveillance epidemiology hospitalization Medicine R
Acceso en línea:	https://doaj.org/article/cf8a080c51b54d31af0cb2aa63c25795
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spelling	oai:doaj.org-article:cf8a080c51b54d31af0cb2aa63c257952021-11-25T19:11:34ZChanging Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy10.3390/vaccines91113542076-393Xhttps://doaj.org/article/cf8a080c51b54d31af0cb2aa63c257952021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1354https://doaj.org/toc/2076-393XDifferences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (<i>p</i> < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection.Daniela LoconsoleFrancesca CentroneCaterina MorcavalloSilvia CampanellaMarisa AccogliAnna SallustioDavide PeccarisiAngela StufanoPiero LovreglioMaria ChironnaMDPI AGarticleSARS-CoV-2 Delta variantSARS-CoV-2 Alpha variantCOVID-19 vaccinesurveillanceepidemiologyhospitalizationMedicineRENVaccines, Vol 9, Iss 1354, p 1354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Delta variant SARS-CoV-2 Alpha variant COVID-19 vaccine surveillance epidemiology hospitalization Medicine R
spellingShingle	SARS-CoV-2 Delta variant SARS-CoV-2 Alpha variant COVID-19 vaccine surveillance epidemiology hospitalization Medicine R Daniela Loconsole Francesca Centrone Caterina Morcavallo Silvia Campanella Marisa Accogli Anna Sallustio Davide Peccarisi Angela Stufano Piero Lovreglio Maria Chironna Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
description	Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (<i>p</i> < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection.
format	article
author	Daniela Loconsole Francesca Centrone Caterina Morcavallo Silvia Campanella Marisa Accogli Anna Sallustio Davide Peccarisi Angela Stufano Piero Lovreglio Maria Chironna
author_facet	Daniela Loconsole Francesca Centrone Caterina Morcavallo Silvia Campanella Marisa Accogli Anna Sallustio Davide Peccarisi Angela Stufano Piero Lovreglio Maria Chironna
author_sort	Daniela Loconsole
title	Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_short	Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_full	Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_fullStr	Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_full_unstemmed	Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_sort	changing features of covid-19: characteristics of infections with the sars-cov-2 delta (b.1.617.2) and alpha (b.1.1.7) variants in southern italy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cf8a080c51b54d31af0cb2aa63c25795
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Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy

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