Impact of polyphenols in phagocyte functions

Leandro Rodrigues da Cunha, Maria Imaculada Muniz-Junqueira, Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Pathology, Faculty of Medicine, University of Brasilia, Brasília, BrazilCorrespondence: Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Patholog...

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Autores principales:	da Cunha LR, Muniz-Junqueira MI, dos Santos Borges TK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	polyphenols inflammation macrophage activation cytokine modulation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cf8c137789f04fc4aba6bd8490eb20a1
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spelling	oai:doaj.org-article:cf8c137789f04fc4aba6bd8490eb20a12021-12-02T03:40:41ZImpact of polyphenols in phagocyte functions1178-7031https://doaj.org/article/cf8c137789f04fc4aba6bd8490eb20a12019-08-01T00:00:00Zhttps://www.dovepress.com/impact-of-polyphenols-in-phagocyte-functions-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Leandro Rodrigues da Cunha, Maria Imaculada Muniz-Junqueira, Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Pathology, Faculty of Medicine, University of Brasilia, Brasília, BrazilCorrespondence: Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Pathology, Faculty of Medicine, University of Brasilia, Campus Darcy Ribeiro, Brasilia, Distrito Federal 70.910.900, BrazilEmail tatianakarlab@gmail.comAbstract: Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.Keywords: polyphenols, inflammation, macrophage activation, cytokine modulationda Cunha LRMuniz-Junqueira MIdos Santos Borges TKDove Medical Pressarticlepolyphenolsinflammationmacrophage activationcytokine modulationPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 12, Pp 205-217 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyphenols inflammation macrophage activation cytokine modulation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	polyphenols inflammation macrophage activation cytokine modulation Pathology RB1-214 Therapeutics. Pharmacology RM1-950 da Cunha LR Muniz-Junqueira MI dos Santos Borges TK Impact of polyphenols in phagocyte functions
description	Leandro Rodrigues da Cunha, Maria Imaculada Muniz-Junqueira, Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Pathology, Faculty of Medicine, University of Brasilia, Brasília, BrazilCorrespondence: Tatiana Karla dos Santos BorgesLaboratory of Cellular Immunology, Pathology, Faculty of Medicine, University of Brasilia, Campus Darcy Ribeiro, Brasilia, Distrito Federal 70.910.900, BrazilEmail tatianakarlab@gmail.comAbstract: Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.Keywords: polyphenols, inflammation, macrophage activation, cytokine modulation
format	article
author	da Cunha LR Muniz-Junqueira MI dos Santos Borges TK
author_facet	da Cunha LR Muniz-Junqueira MI dos Santos Borges TK
author_sort	da Cunha LR
title	Impact of polyphenols in phagocyte functions
title_short	Impact of polyphenols in phagocyte functions
title_full	Impact of polyphenols in phagocyte functions
title_fullStr	Impact of polyphenols in phagocyte functions
title_full_unstemmed	Impact of polyphenols in phagocyte functions
title_sort	impact of polyphenols in phagocyte functions
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/cf8c137789f04fc4aba6bd8490eb20a1
work_keys_str_mv	AT dacunhalr impactofpolyphenolsinphagocytefunctions AT munizjunqueirami impactofpolyphenolsinphagocytefunctions AT dossantosborgestk impactofpolyphenolsinphagocytefunctions
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Impact of polyphenols in phagocyte functions

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