Freeform 3D printing of vascularized tissues: Challenges and strategies

In recent years, freeform three-dimensional (3D) printing has led to significant advances in the fabrication of artificial tissues with vascularized structures. This technique utilizes a supporting matrix that holds the extruded printing ink and ensures shape maintenance of the printed 3D constructs...

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Autores principales:	Hyun Lee, Tae-Sik Jang, Ginam Han, Hae-Won Kim, Hyun-Do Jung
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/cf90fced03324ec78cc018e33a3be9ce
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spelling	oai:doaj.org-article:cf90fced03324ec78cc018e33a3be9ce2021-12-01T00:05:59ZFreeform 3D printing of vascularized tissues: Challenges and strategies2041-731410.1177/20417314211057236https://doaj.org/article/cf90fced03324ec78cc018e33a3be9ce2021-11-01T00:00:00Zhttps://doi.org/10.1177/20417314211057236https://doaj.org/toc/2041-7314In recent years, freeform three-dimensional (3D) printing has led to significant advances in the fabrication of artificial tissues with vascularized structures. This technique utilizes a supporting matrix that holds the extruded printing ink and ensures shape maintenance of the printed 3D constructs within the prescribed spatial precision. Since the printing nozzle can be translated omnidirectionally within the supporting matrix, freeform 3D printing is potentially applicable for the fabrication of complex 3D objects, incorporating curved, and irregular shaped vascular networks. To optimize freeform 3D printing quality and performance, the rheological properties of the printing ink and supporting matrix, and the material matching between them are of paramount importance. In this review, we shall compare conventional 3D printing and freeform 3D printing technologies for the fabrication of vascular constructs, and critically discuss their working principles and their advantages and disadvantages. We also provide the detailed material information of emerging printing inks and supporting matrices in recent freeform 3D printing studies. The accompanying challenges are further discussed, aiming to guide freeform 3D printing by the effective design and selection of the most appropriate materials/processes for the development of full-scale functional vascularized artificial tissues.Hyun LeeTae-Sik JangGinam HanHae-Won KimHyun-Do JungSAGE PublishingarticleBiochemistryQD415-436ENJournal of Tissue Engineering, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biochemistry QD415-436
spellingShingle	Biochemistry QD415-436 Hyun Lee Tae-Sik Jang Ginam Han Hae-Won Kim Hyun-Do Jung Freeform 3D printing of vascularized tissues: Challenges and strategies
description	In recent years, freeform three-dimensional (3D) printing has led to significant advances in the fabrication of artificial tissues with vascularized structures. This technique utilizes a supporting matrix that holds the extruded printing ink and ensures shape maintenance of the printed 3D constructs within the prescribed spatial precision. Since the printing nozzle can be translated omnidirectionally within the supporting matrix, freeform 3D printing is potentially applicable for the fabrication of complex 3D objects, incorporating curved, and irregular shaped vascular networks. To optimize freeform 3D printing quality and performance, the rheological properties of the printing ink and supporting matrix, and the material matching between them are of paramount importance. In this review, we shall compare conventional 3D printing and freeform 3D printing technologies for the fabrication of vascular constructs, and critically discuss their working principles and their advantages and disadvantages. We also provide the detailed material information of emerging printing inks and supporting matrices in recent freeform 3D printing studies. The accompanying challenges are further discussed, aiming to guide freeform 3D printing by the effective design and selection of the most appropriate materials/processes for the development of full-scale functional vascularized artificial tissues.
format	article
author	Hyun Lee Tae-Sik Jang Ginam Han Hae-Won Kim Hyun-Do Jung
author_facet	Hyun Lee Tae-Sik Jang Ginam Han Hae-Won Kim Hyun-Do Jung
author_sort	Hyun Lee
title	Freeform 3D printing of vascularized tissues: Challenges and strategies
title_short	Freeform 3D printing of vascularized tissues: Challenges and strategies
title_full	Freeform 3D printing of vascularized tissues: Challenges and strategies
title_fullStr	Freeform 3D printing of vascularized tissues: Challenges and strategies
title_full_unstemmed	Freeform 3D printing of vascularized tissues: Challenges and strategies
title_sort	freeform 3d printing of vascularized tissues: challenges and strategies
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/cf90fced03324ec78cc018e33a3be9ce
work_keys_str_mv	AT hyunlee freeform3dprintingofvascularizedtissueschallengesandstrategies AT taesikjang freeform3dprintingofvascularizedtissueschallengesandstrategies AT ginamhan freeform3dprintingofvascularizedtissueschallengesandstrategies AT haewonkim freeform3dprintingofvascularizedtissueschallengesandstrategies AT hyundojung freeform3dprintingofvascularizedtissueschallengesandstrategies
_version_	1718406165889548288

Freeform 3D printing of vascularized tissues: Challenges and strategies

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