Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Abstract: The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine...

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Autores principales: Zhang H, Sun ZQ, Liu SS, Yang LN
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
GRK4
DRD1
Hypertension
Meta-analysis
Gene polymorphism
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/cf9571df73df4ae8b0351a0e82d56919
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spelling oai:doaj.org-article:cf9571df73df4ae8b0351a0e82d569192021-12-02T00:42:08ZAssociation between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis1178-1998https://doaj.org/article/cf9571df73df4ae8b0351a0e82d569192015-12-01T00:00:00Zhttps://www.dovepress.com/association-between-grk4-and-drd1-gene-polymorphisms-and-hypertension--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Abstract: The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine whether GRK4 and DRD1 polymorphisms influence the risk of hypertension and examined the relationship between the genetic variances and the etiology of hypertension. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, and sensitivity analysis were performed. A total of 15 articles containing 29 studies were finally included. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016–1.802, P=0.038). Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215–2.745, P=0.004) but not in East Asians and Africans. Rs4532 locus was associated with hypertension in East Asians (OR =1.833, 95% CI =1.415–2.376, P<0.001) but not in Caucasians. These data provide possible references for future case-control studies in hypertension. Keywords: GRK4, DRD1, hypertension, meta-analysis, gene polymorphismZhang HSun ZQLiu SSYang LNDove Medical PressarticleGRK4DRD1HypertensionMeta-analysisGene polymorphismGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 17-27 (2015)
institution DOAJ
collection DOAJ
language EN
topic GRK4
DRD1
Hypertension
Meta-analysis
Gene polymorphism
Geriatrics
RC952-954.6
spellingShingle GRK4
DRD1
Hypertension
Meta-analysis
Gene polymorphism
Geriatrics
RC952-954.6
Zhang H
Sun ZQ
Liu SS
Yang LN
Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
description He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Abstract: The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine whether GRK4 and DRD1 polymorphisms influence the risk of hypertension and examined the relationship between the genetic variances and the etiology of hypertension. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, and sensitivity analysis were performed. A total of 15 articles containing 29 studies were finally included. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016–1.802, P=0.038). Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215–2.745, P=0.004) but not in East Asians and Africans. Rs4532 locus was associated with hypertension in East Asians (OR =1.833, 95% CI =1.415–2.376, P<0.001) but not in Caucasians. These data provide possible references for future case-control studies in hypertension. Keywords: GRK4, DRD1, hypertension, meta-analysis, gene polymorphism
format article
author Zhang H
Sun ZQ
Liu SS
Yang LN
author_facet Zhang H
Sun ZQ
Liu SS
Yang LN
author_sort Zhang H
title Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
title_short Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
title_full Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
title_fullStr Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
title_full_unstemmed Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis
title_sort association between grk4 and drd1 gene polymorphisms and hypertension: a meta-analysis
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/cf9571df73df4ae8b0351a0e82d56919
work_keys_str_mv AT zhangh associationbetweengrk4anddrd1genepolymorphismsandhypertensionametaanalysis
AT sunzq associationbetweengrk4anddrd1genepolymorphismsandhypertensionametaanalysis
AT liuss associationbetweengrk4anddrd1genepolymorphismsandhypertensionametaanalysis
AT yangln associationbetweengrk4anddrd1genepolymorphismsandhypertensionametaanalysis
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