Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.

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Autores principales:	Clint L. Miller, Milos Pjanic, Ting Wang, Trieu Nguyen, Ariella Cohain, Jonathan D. Lee, Ljubica Perisic, Ulf Hedin, Ramendra K. Kundu, Deshna Majmudar, Juyong B. Kim, Oliver Wang, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Themistocles L. Assimes, Stephen B. Montgomery, Eric E. Schadt, Johan L.M. Björkegren, Thomas Quertermous
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf9af3cf26bf44b0ab0e9246393278dd
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spelling	oai:doaj.org-article:cf9af3cf26bf44b0ab0e9246393278dd2021-12-02T15:34:57ZIntegrative functional genomics identifies regulatory mechanisms at coronary artery disease loci10.1038/ncomms120922041-1723https://doaj.org/article/cf9af3cf26bf44b0ab0e9246393278dd2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12092https://doaj.org/toc/2041-1723Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.Clint L. MillerMilos PjanicTing WangTrieu NguyenAriella CohainJonathan D. LeeLjubica PerisicUlf HedinRamendra K. KunduDeshna MajmudarJuyong B. KimOliver WangChrister BetsholtzArno RuusaleppOscar FranzénThemistocles L. AssimesStephen B. MontgomeryEric E. SchadtJohan L.M. BjörkegrenThomas QuertermousNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clint L. Miller Milos Pjanic Ting Wang Trieu Nguyen Ariella Cohain Jonathan D. Lee Ljubica Perisic Ulf Hedin Ramendra K. Kundu Deshna Majmudar Juyong B. Kim Oliver Wang Christer Betsholtz Arno Ruusalepp Oscar Franzén Themistocles L. Assimes Stephen B. Montgomery Eric E. Schadt Johan L.M. Björkegren Thomas Quertermous Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
description	Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.
format	article
author	Clint L. Miller Milos Pjanic Ting Wang Trieu Nguyen Ariella Cohain Jonathan D. Lee Ljubica Perisic Ulf Hedin Ramendra K. Kundu Deshna Majmudar Juyong B. Kim Oliver Wang Christer Betsholtz Arno Ruusalepp Oscar Franzén Themistocles L. Assimes Stephen B. Montgomery Eric E. Schadt Johan L.M. Björkegren Thomas Quertermous
author_facet	Clint L. Miller Milos Pjanic Ting Wang Trieu Nguyen Ariella Cohain Jonathan D. Lee Ljubica Perisic Ulf Hedin Ramendra K. Kundu Deshna Majmudar Juyong B. Kim Oliver Wang Christer Betsholtz Arno Ruusalepp Oscar Franzén Themistocles L. Assimes Stephen B. Montgomery Eric E. Schadt Johan L.M. Björkegren Thomas Quertermous
author_sort	Clint L. Miller
title	Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
title_short	Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
title_full	Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
title_fullStr	Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
title_full_unstemmed	Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
title_sort	integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cf9af3cf26bf44b0ab0e9246393278dd
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Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

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