Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study

Objectives: Few studies have reported clinical COVID-19 sequelae six months (M6) after hospital discharge, but none has studied symptom severity. Methods: Prevalence and severity of 7 symptoms were estimated until M6 using the self-administered influenza severity scale in COVID-19 hospitalized patie...

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Autores principales:	Philippine ELOY, Coralie TARDIVON, Guillaume MARTIN-BLONDEL, Margaux ISNARD, Paul LE TURNIER, Marion LE MARECHAL, André CABIÉ, Odile LAUNAY, Pierre TATTEVIN, Eric SENNEVILLE, Séverine ANSART, François GOEHRINGER, Catherine CHIROUZE, Laurane BOUSSON, Cédric LAOUÉNAN, Manuel ETIENNE, Duc NGUYEN, Jade GHOSN, Xavier DUVAL
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 Sequelae Persistent symptoms Risk factors Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cfa0c26223544d298b5334fcc69a04ae
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spelling	oai:doaj.org-article:cfa0c26223544d298b5334fcc69a04ae2021-11-30T04:14:11ZSeverity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study1201-971210.1016/j.ijid.2021.09.011https://doaj.org/article/cfa0c26223544d298b5334fcc69a04ae2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007244https://doaj.org/toc/1201-9712Objectives: Few studies have reported clinical COVID-19 sequelae six months (M6) after hospital discharge, but none has studied symptom severity. Methods: Prevalence and severity of 7 symptoms were estimated until M6 using the self-administered influenza severity scale in COVID-19 hospitalized patients enrolled in the French COVID cohort. Factors associated with severity were assessed by logistic regression. Anxiety, depression and health-related quality of life (HRQL) were also assessed. Results: At M6, among the 324 patients (median age 61 years, 63% men, 19% admitted to intensive care during the acute phase), 187/324 (58%) reported at least one symptom, mostly fatigue (47%) and myalgia (23%). Symptom severity was scored, at most, mild in 125 (67%), moderate in 44 (23%) and severe in 18 (10%). Female gender was the sole factor associated with moderate/severe symptom reporting (OR = 1.98, 95%CI=1.13-3.47). Among the 225 patients with psychological assessment, 24 (11%) had anxiety, 18 (8%) depressive symptoms, and their physical HRQL was significantly poorer than the general population (p=0.0005). Conclusion: Even if 58% of patients reported ≥1 symptom at M6, less than 7% rated any symptom as severe. Assessing symptoms severity could be helpful to identify patients requiring appropriate medical care. Women may require special attention.Philippine ELOYCoralie TARDIVONGuillaume MARTIN-BLONDELMargaux ISNARDPaul LE TURNIERMarion LE MARECHALAndré CABIÉOdile LAUNAYPierre TATTEVINEric SENNEVILLESéverine ANSARTFrançois GOEHRINGERCatherine CHIROUZELaurane BOUSSONCédric LAOUÉNANManuel ETIENNEDuc NGUYENJade GHOSNXavier DUVALElsevierarticleCOVID-19SequelaePersistent symptomsRisk factorsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 247-253 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Sequelae Persistent symptoms Risk factors Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 Sequelae Persistent symptoms Risk factors Infectious and parasitic diseases RC109-216 Philippine ELOY Coralie TARDIVON Guillaume MARTIN-BLONDEL Margaux ISNARD Paul LE TURNIER Marion LE MARECHAL André CABIÉ Odile LAUNAY Pierre TATTEVIN Eric SENNEVILLE Séverine ANSART François GOEHRINGER Catherine CHIROUZE Laurane BOUSSON Cédric LAOUÉNAN Manuel ETIENNE Duc NGUYEN Jade GHOSN Xavier DUVAL Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
description	Objectives: Few studies have reported clinical COVID-19 sequelae six months (M6) after hospital discharge, but none has studied symptom severity. Methods: Prevalence and severity of 7 symptoms were estimated until M6 using the self-administered influenza severity scale in COVID-19 hospitalized patients enrolled in the French COVID cohort. Factors associated with severity were assessed by logistic regression. Anxiety, depression and health-related quality of life (HRQL) were also assessed. Results: At M6, among the 324 patients (median age 61 years, 63% men, 19% admitted to intensive care during the acute phase), 187/324 (58%) reported at least one symptom, mostly fatigue (47%) and myalgia (23%). Symptom severity was scored, at most, mild in 125 (67%), moderate in 44 (23%) and severe in 18 (10%). Female gender was the sole factor associated with moderate/severe symptom reporting (OR = 1.98, 95%CI=1.13-3.47). Among the 225 patients with psychological assessment, 24 (11%) had anxiety, 18 (8%) depressive symptoms, and their physical HRQL was significantly poorer than the general population (p=0.0005). Conclusion: Even if 58% of patients reported ≥1 symptom at M6, less than 7% rated any symptom as severe. Assessing symptoms severity could be helpful to identify patients requiring appropriate medical care. Women may require special attention.
format	article
author	Philippine ELOY Coralie TARDIVON Guillaume MARTIN-BLONDEL Margaux ISNARD Paul LE TURNIER Marion LE MARECHAL André CABIÉ Odile LAUNAY Pierre TATTEVIN Eric SENNEVILLE Séverine ANSART François GOEHRINGER Catherine CHIROUZE Laurane BOUSSON Cédric LAOUÉNAN Manuel ETIENNE Duc NGUYEN Jade GHOSN Xavier DUVAL
author_facet	Philippine ELOY Coralie TARDIVON Guillaume MARTIN-BLONDEL Margaux ISNARD Paul LE TURNIER Marion LE MARECHAL André CABIÉ Odile LAUNAY Pierre TATTEVIN Eric SENNEVILLE Séverine ANSART François GOEHRINGER Catherine CHIROUZE Laurane BOUSSON Cédric LAOUÉNAN Manuel ETIENNE Duc NGUYEN Jade GHOSN Xavier DUVAL
author_sort	Philippine ELOY
title	Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
title_short	Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
title_full	Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
title_fullStr	Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
title_full_unstemmed	Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study
title_sort	severity of self-reported symptoms and psychological burden 6-months after hospital admission for covid-19: a prospective cohort study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cfa0c26223544d298b5334fcc69a04ae
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Severity of self-reported symptoms and psychological burden 6-months after hospital admission for COVID-19: a prospective cohort study

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