Standardization of Diploid <i>Codonopsis laceolata</i> Root Extract as an Anti-Hyperuricemic Source
<i>Codonopsis lanceolate</i> exerts various medicinal effects and has been used as a traditional medicine for inflammation, asthma, gastritis, and liver disease. Recently, we reported the xanthine oxidase inhibitory activity of <i>C. lanceolata</i> extract and that lobetyolin...
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| Auteurs principaux: | , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
MDPI AG
2021
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| Accès en ligne: | https://doaj.org/article/cfa321f6200842aeb2d6540a9fc73fb6 |
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| Résumé: | <i>Codonopsis lanceolate</i> exerts various medicinal effects and has been used as a traditional medicine for inflammation, asthma, gastritis, and liver disease. Recently, we reported the xanthine oxidase inhibitory activity of <i>C. lanceolata</i> extract and that lobetyolin, one of the key components, was a xanthine oxidase inhibitor. Lobetyolin showed anti-hyperuricemic activity in vitro and in vivo. In this study, we prepared various types of <i>C. lanceolata</i> extracts for the development of functional materials and natural drugs. We present the optimal analytical approach for the quality control and extraction optimization of <i>C. lanceolata</i> preparations. We established and validated a HPLC analysis for easy separation and quantification of the lobetyolin biomarker. Solvent extracts of <i>C. lanceolata</i> root were prepared and the profiles of the active marker and the optimal extraction methods were evaluated. The 100% ethanolic extract demonstrated the highest lobetyolin content. The validated HPLC method confirmed that lobetyolin was present in <i>C. lanceolata</i> root extracts. We suggest that the anti-hyperuricemic activities of <i>C. lanceolata</i> extract could be attributed to this marker compound. The results proposed that the 100% ethanolic extract could be used for the prevention of hyperurecemia, and that this analytical method and biomarker could be useful for the quality control of <i>C. lanceolata</i> preparations. |
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