Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats

Background: The continued use of bromate due to its oxidizing property poses health hazards since it is an established nephrotoxic agent. Objectives: This study evaluated the capacity of the ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxicity of potassium bromate in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Israel Ehizuelen Ebhohimen, Ngozi Paulinus Okolie
Formato:	article
Lenguaje:	EN
Publicado:	Hamadan University of Medical Sciences 2021
Materias:	aframomum angustifolium bromate nephrotoxicity reno-protection phytochemicals Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/cfa9241e0c8c4312b5c783a24ec72bc2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cfa9241e0c8c4312b5c783a24ec72bc2
record_format	dspace
spelling	oai:doaj.org-article:cfa9241e0c8c4312b5c783a24ec72bc22021-11-23T10:20:45ZEffect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats10.34172/ajmb.2021.022345-4113https://doaj.org/article/cfa9241e0c8c4312b5c783a24ec72bc22021-06-01T00:00:00Zhttp://ajmb.umsha.ac.ir/PDF/ajmb-9-8.pdfhttps://doaj.org/toc/2345-4113Background: The continued use of bromate due to its oxidizing property poses health hazards since it is an established nephrotoxic agent. Objectives: This study evaluated the capacity of the ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxicity of potassium bromate in Wistar rats. Methods: In stage I of this study, the main phytochemical groups in the seeds were quantified using spectrophotometric procedures. The acute and sub-chronic toxicities of the extract were studied by monitoring physical and biochemical parameters in stage II. In stage III, the reno-protective effect of the extract were determined by administering 350 and 750 mg/kg bw of the extract with 30 mg/kg bw potassium bromate orally. The reno-protective study lasted for 56 days and the effect of treatment on biomarkers was determined on days 28 and 56. Results: The phytochemical groups (i.e., alkaloids, flavonoids, saponins, tannins, ascorbic acid, and alpha-tocopherol) were detected in the seeds. The acute and sub-chronic oral administration of the extract did not induce any significant toxic reactions across the studied concentrations. The sub-chronic administration of the extract reduced average weight gain in the treated groups. The obtained results in the reno-protective and histological studies indicated that the seed extract offers protection against the induced oxidative assault by bromate. Conclusion: In general, the co-administration of the ethanol extract of A. angustifolium seeds with bromate can reduce its nephrotoxicity in a dose-dependent manner.Israel Ehizuelen EbhohimenNgozi Paulinus OkolieHamadan University of Medical Sciencesarticleaframomum angustifoliumbromatenephrotoxicityreno-protectionphytochemicalsMedical technologyR855-855.5ENAvicenna Journal of Medical Biochemistry, Vol 9, Iss 1, Pp 8-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aframomum angustifolium bromate nephrotoxicity reno-protection phytochemicals Medical technology R855-855.5
spellingShingle	aframomum angustifolium bromate nephrotoxicity reno-protection phytochemicals Medical technology R855-855.5 Israel Ehizuelen Ebhohimen Ngozi Paulinus Okolie Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
description	Background: The continued use of bromate due to its oxidizing property poses health hazards since it is an established nephrotoxic agent. Objectives: This study evaluated the capacity of the ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxicity of potassium bromate in Wistar rats. Methods: In stage I of this study, the main phytochemical groups in the seeds were quantified using spectrophotometric procedures. The acute and sub-chronic toxicities of the extract were studied by monitoring physical and biochemical parameters in stage II. In stage III, the reno-protective effect of the extract were determined by administering 350 and 750 mg/kg bw of the extract with 30 mg/kg bw potassium bromate orally. The reno-protective study lasted for 56 days and the effect of treatment on biomarkers was determined on days 28 and 56. Results: The phytochemical groups (i.e., alkaloids, flavonoids, saponins, tannins, ascorbic acid, and alpha-tocopherol) were detected in the seeds. The acute and sub-chronic oral administration of the extract did not induce any significant toxic reactions across the studied concentrations. The sub-chronic administration of the extract reduced average weight gain in the treated groups. The obtained results in the reno-protective and histological studies indicated that the seed extract offers protection against the induced oxidative assault by bromate. Conclusion: In general, the co-administration of the ethanol extract of A. angustifolium seeds with bromate can reduce its nephrotoxicity in a dose-dependent manner.
format	article
author	Israel Ehizuelen Ebhohimen Ngozi Paulinus Okolie
author_facet	Israel Ehizuelen Ebhohimen Ngozi Paulinus Okolie
author_sort	Israel Ehizuelen Ebhohimen
title	Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
title_short	Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
title_full	Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
title_fullStr	Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
title_full_unstemmed	Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats
title_sort	effect of ethanol extract of aframomum angustifolium seed on the induction of nephrotoxicity by bromate in wistar rats
publisher	Hamadan University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/cfa9241e0c8c4312b5c783a24ec72bc2
work_keys_str_mv	AT israelehizuelenebhohimen effectofethanolextractofaframomumangustifoliumseedontheinductionofnephrotoxicitybybromateinwistarrats AT ngozipaulinusokolie effectofethanolextractofaframomumangustifoliumseedontheinductionofnephrotoxicitybybromateinwistarrats
_version_	1718416793645613056

Effect of Ethanol Extract of Aframomum angustifolium Seed on the Induction of Nephrotoxicity by Bromate in Wistar Rats

Ejemplares similares