Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-II proteins and can stimulate CD4 + T-cells.

Guardado en:
Detalles Bibliográficos
Autores principales: Vijaya L. Simhadri, Louis Hopkins, Joseph R. McGill, Brian R. Duke, Swati Mukherjee, Kate Zhang, Zuben E. Sauna
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-II proteins and can stimulate CD4 + T-cells.