Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-II proteins and can stimulate CD4 + T-cells.

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Autores principales:	Vijaya L. Simhadri, Louis Hopkins, Joseph R. McGill, Brian R. Duke, Swati Mukherjee, Kate Zhang, Zuben E. Sauna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
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spelling	oai:doaj.org-article:cfab9360e97b4aa380519906ce6d72732021-12-02T15:09:09ZCas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells10.1038/s41467-021-25414-92041-1723https://doaj.org/article/cfab9360e97b4aa380519906ce6d72732021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25414-9https://doaj.org/toc/2041-1723There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-II proteins and can stimulate CD4 + T-cells.Vijaya L. SimhadriLouis HopkinsJoseph R. McGillBrian R. DukeSwati MukherjeeKate ZhangZuben E. SaunaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vijaya L. Simhadri Louis Hopkins Joseph R. McGill Brian R. Duke Swati Mukherjee Kate Zhang Zuben E. Sauna Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
description	There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-II proteins and can stimulate CD4 + T-cells.
format	article
author	Vijaya L. Simhadri Louis Hopkins Joseph R. McGill Brian R. Duke Swati Mukherjee Kate Zhang Zuben E. Sauna
author_facet	Vijaya L. Simhadri Louis Hopkins Joseph R. McGill Brian R. Duke Swati Mukherjee Kate Zhang Zuben E. Sauna
author_sort	Vijaya L. Simhadri
title	Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
title_short	Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
title_full	Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
title_fullStr	Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
title_full_unstemmed	Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells
title_sort	cas9-derived peptides presented by mhc class ii that elicit proliferation of cd4+ t-cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
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Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

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