Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats

Motoo Kobayashi,1,2,* Yuki Okada,1,2,* Hiromichi Ueno,1 Takayuki Mizorogi,1 Kenji Ohara,1 Koh Kawasumi,1 Kohei Suruga,3 Kazunari Kadokura,3 Yasuyuki Ohnishi,2 Toshiro Arai1,2 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kobayashi M, Okada Y, Ueno H, Mizorogi T, Ohara K, Kawasumi K, Suruga K, Kadokura K, Ohnishi Y, Arai T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	anti-inflammatory compound cat obesity quercetin saa Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/cfad0d48826d4fa59aa10f5549e42954
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cfad0d48826d4fa59aa10f5549e42954
record_format	dspace
spelling	oai:doaj.org-article:cfad0d48826d4fa59aa10f5549e429542021-12-02T08:31:21ZEffects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats2230-2034https://doaj.org/article/cfad0d48826d4fa59aa10f5549e429542020-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-supplementation-with-anti-inflammatory-compound-extracted-f-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Motoo Kobayashi,1,2,* Yuki Okada,1,2,* Hiromichi Ueno,1 Takayuki Mizorogi,1 Kenji Ohara,1 Koh Kawasumi,1 Kohei Suruga,3 Kazunari Kadokura,3 Yasuyuki Ohnishi,2 Toshiro Arai1,2 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8601, Japan; 2One Health Co. Ltd, Tokyo 157-0066, Japan; 3Food Function R&D Division, International Operation Department, Kibun Foods Inc., Tokyo 206-0812, Japan*These authors contributed equally to this workCorrespondence: Toshiro AraiLaboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8601, JapanTel +81 422 31 4151Fax +81 422 31 7841Email tarai@nvlu.ac.jpBackground: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats.Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Anti-inflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100– 120 mg/kg/day (2.5– 3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation.Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation.Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.Keywords: anti-inflammatory compound, cat, obesity, quercetin, SAAKobayashi MOkada YUeno HMizorogi TOhara KKawasumi KSuruga KKadokura KOhnishi YArai TDove Medical Pressarticleanti-inflammatory compoundcatobesityquercetinsaaVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 11, Pp 39-44 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-inflammatory compound cat obesity quercetin saa Veterinary medicine SF600-1100
spellingShingle	anti-inflammatory compound cat obesity quercetin saa Veterinary medicine SF600-1100 Kobayashi M Okada Y Ueno H Mizorogi T Ohara K Kawasumi K Suruga K Kadokura K Ohnishi Y Arai T Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
description	Motoo Kobayashi,1,2,* Yuki Okada,1,2,* Hiromichi Ueno,1 Takayuki Mizorogi,1 Kenji Ohara,1 Koh Kawasumi,1 Kohei Suruga,3 Kazunari Kadokura,3 Yasuyuki Ohnishi,2 Toshiro Arai1,2 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8601, Japan; 2One Health Co. Ltd, Tokyo 157-0066, Japan; 3Food Function R&D Division, International Operation Department, Kibun Foods Inc., Tokyo 206-0812, Japan*These authors contributed equally to this workCorrespondence: Toshiro AraiLaboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8601, JapanTel +81 422 31 4151Fax +81 422 31 7841Email tarai@nvlu.ac.jpBackground: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats.Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Anti-inflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100– 120 mg/kg/day (2.5– 3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation.Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation.Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.Keywords: anti-inflammatory compound, cat, obesity, quercetin, SAA
format	article
author	Kobayashi M Okada Y Ueno H Mizorogi T Ohara K Kawasumi K Suruga K Kadokura K Ohnishi Y Arai T
author_facet	Kobayashi M Okada Y Ueno H Mizorogi T Ohara K Kawasumi K Suruga K Kadokura K Ohnishi Y Arai T
author_sort	Kobayashi M
title	Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
title_short	Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
title_full	Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
title_fullStr	Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
title_full_unstemmed	Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats
title_sort	effects of supplementation with anti-inflammatory compound extracted from herbs in healthy and obese cats
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cfad0d48826d4fa59aa10f5549e42954
work_keys_str_mv	AT kobayashim effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT okaday effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT uenoh effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT mizorogit effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT oharak effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT kawasumik effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT surugak effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT kadokurak effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT ohnishiy effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats AT arait effectsofsupplementationwithantiinflammatorycompoundextractedfromherbsinhealthyandobesecats
_version_	1718398509257850880

Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats

Ejemplares similares