Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device

Abstract Radioactive iodine (RAI) is safe and effective in most patients with hyperthyroidism but not all individuals are cured by the first dose, and most develop post-RAI hypothyroidism. Postoperative RAI therapy for remnant ablation is successful in 80–90% of thyroid cancer patients and sometimes...

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Autores principales:	Prasanna Santhanam, Lilja Solnes, Tanmay Nath, Jean-Paul Roussin, David Gray, Eric Frey, George Sgouros, Paul W. Ladenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cfaf29c62f4a4d59a2443ed134a1cda2
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spelling	oai:doaj.org-article:cfaf29c62f4a4d59a2443ed134a1cda22021-12-02T17:25:43ZReal-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device10.1038/s41598-021-97408-y2045-2322https://doaj.org/article/cfaf29c62f4a4d59a2443ed134a1cda22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97408-yhttps://doaj.org/toc/2045-2322Abstract Radioactive iodine (RAI) is safe and effective in most patients with hyperthyroidism but not all individuals are cured by the first dose, and most develop post-RAI hypothyroidism. Postoperative RAI therapy for remnant ablation is successful in 80–90% of thyroid cancer patients and sometimes induces remission of nonresectable cervical and/or distant metastatic disease but the effective tumor dose is usually not precisely known and must be moderated to avoid short- and long-term adverse effects on other tissues. The Collar Therapy Indicator (COTI) is a radiation detection device embedded in a cloth collar secured around the patient’s neck and connected to a recording and data transmission box. In previously published experience, the data can be collected at multiple time points, reflecting local cervical RAI exposure and correlating well with conventional methods. We evaluated the real-time uptake of RAI in patients with hyperthyroid Graves’ disease and thyroid cancer. We performed a pilot feasibility prospective study. Data were analyzed using R© (version 4.0.3, The R Foundation for Statistical Computing, 2020), and Python (version 3.6, Matplotlib version 3.0.3). The COTI was able to provide a quantitative temporal pattern of uptake within the thyroid in persons with Graves’ disease and lateralized the remnant tissue in persons with thyroid cancer. The study has demonstrated that the portable collar radiation detection device outside of a healthcare facility is accurate and feasible for use after administration of RAI for diagnostic studies and therapy to provide a complete collection of fractional target radioactivity data compared to that traditionally acquired with clinic-based measurements at one or two time-points. Clinical Trials Registration NCT03517579, DOR 5/7/2018.Prasanna SanthanamLilja SolnesTanmay NathJean-Paul RoussinDavid GrayEric FreyGeorge SgourosPaul W. LadensonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Prasanna Santhanam Lilja Solnes Tanmay Nath Jean-Paul Roussin David Gray Eric Frey George Sgouros Paul W. Ladenson Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
description	Abstract Radioactive iodine (RAI) is safe and effective in most patients with hyperthyroidism but not all individuals are cured by the first dose, and most develop post-RAI hypothyroidism. Postoperative RAI therapy for remnant ablation is successful in 80–90% of thyroid cancer patients and sometimes induces remission of nonresectable cervical and/or distant metastatic disease but the effective tumor dose is usually not precisely known and must be moderated to avoid short- and long-term adverse effects on other tissues. The Collar Therapy Indicator (COTI) is a radiation detection device embedded in a cloth collar secured around the patient’s neck and connected to a recording and data transmission box. In previously published experience, the data can be collected at multiple time points, reflecting local cervical RAI exposure and correlating well with conventional methods. We evaluated the real-time uptake of RAI in patients with hyperthyroid Graves’ disease and thyroid cancer. We performed a pilot feasibility prospective study. Data were analyzed using R© (version 4.0.3, The R Foundation for Statistical Computing, 2020), and Python (version 3.6, Matplotlib version 3.0.3). The COTI was able to provide a quantitative temporal pattern of uptake within the thyroid in persons with Graves’ disease and lateralized the remnant tissue in persons with thyroid cancer. The study has demonstrated that the portable collar radiation detection device outside of a healthcare facility is accurate and feasible for use after administration of RAI for diagnostic studies and therapy to provide a complete collection of fractional target radioactivity data compared to that traditionally acquired with clinic-based measurements at one or two time-points. Clinical Trials Registration NCT03517579, DOR 5/7/2018.
format	article
author	Prasanna Santhanam Lilja Solnes Tanmay Nath Jean-Paul Roussin David Gray Eric Frey George Sgouros Paul W. Ladenson
author_facet	Prasanna Santhanam Lilja Solnes Tanmay Nath Jean-Paul Roussin David Gray Eric Frey George Sgouros Paul W. Ladenson
author_sort	Prasanna Santhanam
title	Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
title_short	Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
title_full	Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
title_fullStr	Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
title_full_unstemmed	Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
title_sort	real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cfaf29c62f4a4d59a2443ed134a1cda2
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Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device

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