Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Ping Ma,1,2,* Qing Luo,2,* Jiaoe Chen,1 Yaping Gan,1 Juan Du,2 Shumao Ding,2 Zhuge Xi,3 Xu Yang2 1College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, People's Republic of China; 2Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Coll...

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Autores principales: Ma P, Luo Q, Chen J, Gan Y, Du J, Ding S, Xi Z, Yang X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/cfaf57fead684a24be292f0cfdaef322
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spelling oai:doaj.org-article:cfaf57fead684a24be292f0cfdaef3222021-12-02T05:09:46ZIntraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice1176-91141178-2013https://doaj.org/article/cfaf57fead684a24be292f0cfdaef3222012-09-01T00:00:00Zhttp://www.dovepress.com/intraperitoneal-injection-of-magnetic-fe3o4-nanoparticle-induces-hepat-a10905https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ping Ma,1,2,* Qing Luo,2,* Jiaoe Chen,1 Yaping Gan,1 Juan Du,2 Shumao Ding,2 Zhuge Xi,3 Xu Yang2 1College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, People's Republic of China; 2Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, People's Republic of China; 3Tianjin Institute of Health and Environmental Medicine, Tianjin, People's Republic of China*These authors contributed equally to this workAbstract: Because of its unique magnetic properties, the iron oxide (Fe3O4) nanoparticle has been widely exploited and its application in various fields has promised immense benefits. However, doubts exist over the use of Fe3O4-nanoparticles in human beings. Thus, the aim of the current study was to find out the potential safety range of medical use. Twenty-five Kunming mice were exposed to Fe3O4-nanoparticles via intraperitoneal injection daily for 1 week at doses of 0, 5, 10, 20, and 40 mg/kg. Hepatic and renal tissues were sliced for physiological observation. Injuries were observed in the high-dose groups (20 and 40 mg/kg) compared with the control group (0 mg/kg). Biomarkers of reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, and 8-hydroxy-2'-deoxyguanosine in the hepatic and renal tissues were detected. Injury to tissues and oxidative damage to cells at the molecular level was found. The safest dose recommended from the results of this study is 5 mg/kg, as we believe this to be an upper limit balancing the benefits and risks for sub-long-term exposure.Keywords: Fe3O4-nanoparticles, reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, 8-hydroxy-2'-deoxyguanosineMa PLuo QChen JGan YDu JDing SXi ZYang XDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4809-4818 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Ma P
Luo Q
Chen J
Gan Y
Du J
Ding S
Xi Z
Yang X
Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
description Ping Ma,1,2,* Qing Luo,2,* Jiaoe Chen,1 Yaping Gan,1 Juan Du,2 Shumao Ding,2 Zhuge Xi,3 Xu Yang2 1College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, People's Republic of China; 2Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, People's Republic of China; 3Tianjin Institute of Health and Environmental Medicine, Tianjin, People's Republic of China*These authors contributed equally to this workAbstract: Because of its unique magnetic properties, the iron oxide (Fe3O4) nanoparticle has been widely exploited and its application in various fields has promised immense benefits. However, doubts exist over the use of Fe3O4-nanoparticles in human beings. Thus, the aim of the current study was to find out the potential safety range of medical use. Twenty-five Kunming mice were exposed to Fe3O4-nanoparticles via intraperitoneal injection daily for 1 week at doses of 0, 5, 10, 20, and 40 mg/kg. Hepatic and renal tissues were sliced for physiological observation. Injuries were observed in the high-dose groups (20 and 40 mg/kg) compared with the control group (0 mg/kg). Biomarkers of reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, and 8-hydroxy-2'-deoxyguanosine in the hepatic and renal tissues were detected. Injury to tissues and oxidative damage to cells at the molecular level was found. The safest dose recommended from the results of this study is 5 mg/kg, as we believe this to be an upper limit balancing the benefits and risks for sub-long-term exposure.Keywords: Fe3O4-nanoparticles, reactive oxygen species, glutathione, malondialdehyde, DNA-protein crosslinks, 8-hydroxy-2'-deoxyguanosine
format article
author Ma P
Luo Q
Chen J
Gan Y
Du J
Ding S
Xi Z
Yang X
author_facet Ma P
Luo Q
Chen J
Gan Y
Du J
Ding S
Xi Z
Yang X
author_sort Ma P
title Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
title_short Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
title_full Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
title_fullStr Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
title_full_unstemmed Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
title_sort intraperitoneal injection of magnetic fe3o4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/cfaf57fead684a24be292f0cfdaef322
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