WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shuttling and transcriptional activity of SMAD2 in the...

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Autores principales:	Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad3
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spelling	oai:doaj.org-article:cfb1b8ece2684ea692a537c58f79dad32021-12-02T15:35:57ZWWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling10.1038/s41467-019-11551-92041-1723https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad32019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11551-9https://doaj.org/toc/2041-1723Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shuttling and transcriptional activity of SMAD2 in the diseased heart.Huimei ChenAida Moreno-MoralFrancesco PesceNithya DevapragashMassimiliano ManciniEe Ling HengMaxime RotivalPrashant K. SrivastavaNathan HarmstonKirill ShkuraOwen J. L. RackhamWei-Ping YuXi-Ming SunNicole Gui Zhen TeeElisabeth Li Sa TanPaul J. R. BartonLeanne E. FelkinEnrique Lara-PezziGianni AngeliniCristina BeltramiMichal PravenecSebastian SchaferLeonardo BottoloNorbert HubnerCostanza EmanueliStuart A. CookEnrico PetrettoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huimei Chen Aida Moreno-Moral Francesco Pesce Nithya Devapragash Massimiliano Mancini Ee Ling Heng Maxime Rotival Prashant K. Srivastava Nathan Harmston Kirill Shkura Owen J. L. Rackham Wei-Ping Yu Xi-Ming Sun Nicole Gui Zhen Tee Elisabeth Li Sa Tan Paul J. R. Barton Leanne E. Felkin Enrique Lara-Pezzi Gianni Angelini Cristina Beltrami Michal Pravenec Sebastian Schafer Leonardo Bottolo Norbert Hubner Costanza Emanueli Stuart A. Cook Enrico Petretto WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
description	Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shuttling and transcriptional activity of SMAD2 in the diseased heart.
format	article
author	Huimei Chen Aida Moreno-Moral Francesco Pesce Nithya Devapragash Massimiliano Mancini Ee Ling Heng Maxime Rotival Prashant K. Srivastava Nathan Harmston Kirill Shkura Owen J. L. Rackham Wei-Ping Yu Xi-Ming Sun Nicole Gui Zhen Tee Elisabeth Li Sa Tan Paul J. R. Barton Leanne E. Felkin Enrique Lara-Pezzi Gianni Angelini Cristina Beltrami Michal Pravenec Sebastian Schafer Leonardo Bottolo Norbert Hubner Costanza Emanueli Stuart A. Cook Enrico Petretto
author_facet	Huimei Chen Aida Moreno-Moral Francesco Pesce Nithya Devapragash Massimiliano Mancini Ee Ling Heng Maxime Rotival Prashant K. Srivastava Nathan Harmston Kirill Shkura Owen J. L. Rackham Wei-Ping Yu Xi-Ming Sun Nicole Gui Zhen Tee Elisabeth Li Sa Tan Paul J. R. Barton Leanne E. Felkin Enrique Lara-Pezzi Gianni Angelini Cristina Beltrami Michal Pravenec Sebastian Schafer Leonardo Bottolo Norbert Hubner Costanza Emanueli Stuart A. Cook Enrico Petretto
author_sort	Huimei Chen
title	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
title_short	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
title_full	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
title_fullStr	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
title_full_unstemmed	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
title_sort	wwp2 regulates pathological cardiac fibrosis by modulating smad2 signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad3
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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

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