Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P. Morris, Antony Adamson, Peter Fraser, Magnus Rattray, Stephen Eyre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cfb2cf5b4bb44d5cacaff7677eed292d
record_format	dspace
spelling	oai:doaj.org-article:cfb2cf5b4bb44d5cacaff7677eed292d2021-12-02T19:09:54ZAnalysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis10.1038/s41467-020-18180-72041-1723https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18180-7https://doaj.org/toc/2041-1723Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interactions of expression quantitative trait loci with target genes in rheumatoid arthritis.Jing YangAmanda McGovernPaul MartinKate DuffusXiangyu GePeyman ZarrinehAndrew P. MorrisAntony AdamsonPeter FraserMagnus RattrayStephen EyreNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Yang Amanda McGovern Paul Martin Kate Duffus Xiangyu Ge Peyman Zarrineh Andrew P. Morris Antony Adamson Peter Fraser Magnus Rattray Stephen Eyre Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
description	Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interactions of expression quantitative trait loci with target genes in rheumatoid arthritis.
format	article
author	Jing Yang Amanda McGovern Paul Martin Kate Duffus Xiangyu Ge Peyman Zarrineh Andrew P. Morris Antony Adamson Peter Fraser Magnus Rattray Stephen Eyre
author_facet	Jing Yang Amanda McGovern Paul Martin Kate Duffus Xiangyu Ge Peyman Zarrineh Andrew P. Morris Antony Adamson Peter Fraser Magnus Rattray Stephen Eyre
author_sort	Jing Yang
title	Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
title_short	Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
title_full	Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
title_fullStr	Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
title_full_unstemmed	Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
title_sort	analysis of chromatin organization and gene expression in t cells identifies functional genes for rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d
work_keys_str_mv	AT jingyang analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT amandamcgovern analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT paulmartin analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT kateduffus analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT xiangyuge analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT peymanzarrineh analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT andrewpmorris analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT antonyadamson analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT peterfraser analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT magnusrattray analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis AT stepheneyre analysisofchromatinorganizationandgeneexpressionintcellsidentifiesfunctionalgenesforrheumatoidarthritis
_version_	1718377117835591680

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

Ejemplares similares