Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interac...

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Autores principales: Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P. Morris, Antony Adamson, Peter Fraser, Magnus Rattray, Stephen Eyre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d
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