Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain. Here the authors study whether DPP4 inhibition controls sDPP4 and inflammatory biomarkers, and demonstrate that DPP4 inhibiti...

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Autores principales:	Laurie L. Baggio, Elodie M. Varin, Jacqueline A. Koehler, Xiemin Cao, Yuliya Lokhnygina, Susanna R. Stevens, Rury R. Holman, Daniel J. Drucker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfbe57d96821439588f72940834dce14
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spelling	oai:doaj.org-article:cfbe57d96821439588f72940834dce142021-12-02T16:13:57ZPlasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans10.1038/s41467-020-17556-z2041-1723https://doaj.org/article/cfbe57d96821439588f72940834dce142020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17556-zhttps://doaj.org/toc/2041-1723DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain. Here the authors study whether DPP4 inhibition controls sDPP4 and inflammatory biomarkers, and demonstrate that DPP4 inhibition is dissociated from changes in inflammation in mice and humans.Laurie L. BaggioElodie M. VarinJacqueline A. KoehlerXiemin CaoYuliya LokhnyginaSusanna R. StevensRury R. HolmanDaniel J. DruckerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laurie L. Baggio Elodie M. Varin Jacqueline A. Koehler Xiemin Cao Yuliya Lokhnygina Susanna R. Stevens Rury R. Holman Daniel J. Drucker Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
description	DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain. Here the authors study whether DPP4 inhibition controls sDPP4 and inflammatory biomarkers, and demonstrate that DPP4 inhibition is dissociated from changes in inflammation in mice and humans.
format	article
author	Laurie L. Baggio Elodie M. Varin Jacqueline A. Koehler Xiemin Cao Yuliya Lokhnygina Susanna R. Stevens Rury R. Holman Daniel J. Drucker
author_facet	Laurie L. Baggio Elodie M. Varin Jacqueline A. Koehler Xiemin Cao Yuliya Lokhnygina Susanna R. Stevens Rury R. Holman Daniel J. Drucker
author_sort	Laurie L. Baggio
title	Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
title_short	Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
title_full	Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
title_fullStr	Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
title_full_unstemmed	Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
title_sort	plasma levels of dpp4 activity and sdpp4 are dissociated from inflammation in mice and humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cfbe57d96821439588f72940834dce14
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Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

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