A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT

Abstract Background The commonly used NEMA IEC Body phantom has a number of defects, hindering its application for detecting micro-lesions and measuring the performance parameters of computed tomography (CT). This study aimed to propose a PET/CT phantom designed by National Institute of Metrology (N...

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Autores principales:	Shujie Lu, Peng Zhang, Chengwei Li, Jie Sun, Wenli Liu, Pu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	PET/CT phantom CT performance parameters Image quality Micro-lesions Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/cfc6bc53119244f184697d9aec939fa8
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spelling	oai:doaj.org-article:cfc6bc53119244f184697d9aec939fa82021-11-14T12:33:38ZA NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT10.1186/s12880-021-00683-41471-2342https://doaj.org/article/cfc6bc53119244f184697d9aec939fa82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12880-021-00683-4https://doaj.org/toc/1471-2342Abstract Background The commonly used NEMA IEC Body phantom has a number of defects, hindering its application for detecting micro-lesions and measuring the performance parameters of computed tomography (CT). This study aimed to propose a PET/CT phantom designed by National Institute of Metrology (NIM), China, which is capable of simultaneously testing the performance of PET and CT systems, and to evaluate the quality of imaging. Methods The phantom developed in the present study, the NIM PET/CT phantom, is composed of a PET imaging module and a CT imaging module, and these modules are connected together through bolts, which can simultaneously measure the imaging performance of PET and CT systems. Hot spheres were filled with 4:1 sphere-to-background activity concentration using 18F-fluorodeoxyglucose (18F-FDG), and cold spheres were filled with non-radioactive water. We compared the results of imaging obtained from the NIM PET/CT phantom and the NEMA IEC Body phantom to assess their diagnostic efficacy. In order to evaluate the generalization ability of the NIM PET/CT phantom, three different PET/CT systems were used to scan on the same scanning protocol. To evaluate the effects of image reconstruction algorithms on image quality assessment, ordered subset expectation maximization (OSEM), OSEM-point-spread function (PSF), OSEM-TOF, and OSEM-PSF-TOF algorithms were employed. Results The imaging quality of the NIM PET/CT phantom and the NEMA IEC Body phantom was relatively consistent. The NIM PET/CT phantom could detect 7 mm spheres without influencing the imaging quality. It was found that PSF reconstruction exhibited to reduce the speed of convergence, the contrast and background variability of spheres (13–28 mm) were significantly improved after two iterations. In addition to improve the image contrast and background variability, TOF could markedly improve the overall image quality and instrument detection limit. TOF-PSF could noticeably reduce noise level, enhance imaging details, and improve quality of imaging. Conclusions The results showed that in comparison with the NEMA IEC Body phantom, the NIM PET/CT phantom outperformed in evaluating the PET image quality of micro-lesions and the performance parameters of CT.Shujie LuPeng ZhangChengwei LiJie SunWenli LiuPu ZhangBMCarticlePET/CT phantomCT performance parametersImage qualityMicro-lesionsMedical technologyR855-855.5ENBMC Medical Imaging, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PET/CT phantom CT performance parameters Image quality Micro-lesions Medical technology R855-855.5
spellingShingle	PET/CT phantom CT performance parameters Image quality Micro-lesions Medical technology R855-855.5 Shujie Lu Peng Zhang Chengwei Li Jie Sun Wenli Liu Pu Zhang A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
description	Abstract Background The commonly used NEMA IEC Body phantom has a number of defects, hindering its application for detecting micro-lesions and measuring the performance parameters of computed tomography (CT). This study aimed to propose a PET/CT phantom designed by National Institute of Metrology (NIM), China, which is capable of simultaneously testing the performance of PET and CT systems, and to evaluate the quality of imaging. Methods The phantom developed in the present study, the NIM PET/CT phantom, is composed of a PET imaging module and a CT imaging module, and these modules are connected together through bolts, which can simultaneously measure the imaging performance of PET and CT systems. Hot spheres were filled with 4:1 sphere-to-background activity concentration using 18F-fluorodeoxyglucose (18F-FDG), and cold spheres were filled with non-radioactive water. We compared the results of imaging obtained from the NIM PET/CT phantom and the NEMA IEC Body phantom to assess their diagnostic efficacy. In order to evaluate the generalization ability of the NIM PET/CT phantom, three different PET/CT systems were used to scan on the same scanning protocol. To evaluate the effects of image reconstruction algorithms on image quality assessment, ordered subset expectation maximization (OSEM), OSEM-point-spread function (PSF), OSEM-TOF, and OSEM-PSF-TOF algorithms were employed. Results The imaging quality of the NIM PET/CT phantom and the NEMA IEC Body phantom was relatively consistent. The NIM PET/CT phantom could detect 7 mm spheres without influencing the imaging quality. It was found that PSF reconstruction exhibited to reduce the speed of convergence, the contrast and background variability of spheres (13–28 mm) were significantly improved after two iterations. In addition to improve the image contrast and background variability, TOF could markedly improve the overall image quality and instrument detection limit. TOF-PSF could noticeably reduce noise level, enhance imaging details, and improve quality of imaging. Conclusions The results showed that in comparison with the NEMA IEC Body phantom, the NIM PET/CT phantom outperformed in evaluating the PET image quality of micro-lesions and the performance parameters of CT.
format	article
author	Shujie Lu Peng Zhang Chengwei Li Jie Sun Wenli Liu Pu Zhang
author_facet	Shujie Lu Peng Zhang Chengwei Li Jie Sun Wenli Liu Pu Zhang
author_sort	Shujie Lu
title	A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
title_short	A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
title_full	A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
title_fullStr	A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
title_full_unstemmed	A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT
title_sort	nim pet/ct phantom for evaluating the pet image quality of micro-lesions and the performance parameters of ct
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cfc6bc53119244f184697d9aec939fa8
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A NIM PET/CT phantom for evaluating the PET image quality of micro-lesions and the performance parameters of CT

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