Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part thr...

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Autores principales:	Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser, Masashi Narita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfcc6e6ce1f94a00978bd38e7e46977b
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spelling	oai:doaj.org-article:cfcc6e6ce1f94a00978bd38e7e46977b2021-12-02T17:32:42ZTranscription-dependent cohesin repositioning rewires chromatin loops in cellular senescence10.1038/s41467-020-19878-42041-1723https://doaj.org/article/cfcc6e6ce1f94a00978bd38e7e46977b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19878-4https://doaj.org/toc/2041-1723Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.Ioana OlanAled J. ParryStefan SchoenfelderMasako NaritaYoko ItoAdelyne S. L. ChanGuy St.C. SlaterDóra BiharyMasashige BandoKatsuhiko ShirahigeHiroshi KimuraShamith A. SamarajiwaPeter FraserMasashi NaritaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ioana Olan Aled J. Parry Stefan Schoenfelder Masako Narita Yoko Ito Adelyne S. L. Chan Guy St.C. Slater Dóra Bihary Masashige Bando Katsuhiko Shirahige Hiroshi Kimura Shamith A. Samarajiwa Peter Fraser Masashi Narita Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
description	Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.
format	article
author	Ioana Olan Aled J. Parry Stefan Schoenfelder Masako Narita Yoko Ito Adelyne S. L. Chan Guy St.C. Slater Dóra Bihary Masashige Bando Katsuhiko Shirahige Hiroshi Kimura Shamith A. Samarajiwa Peter Fraser Masashi Narita
author_facet	Ioana Olan Aled J. Parry Stefan Schoenfelder Masako Narita Yoko Ito Adelyne S. L. Chan Guy St.C. Slater Dóra Bihary Masashige Bando Katsuhiko Shirahige Hiroshi Kimura Shamith A. Samarajiwa Peter Fraser Masashi Narita
author_sort	Ioana Olan
title	Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_short	Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_full	Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_fullStr	Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_full_unstemmed	Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
title_sort	transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cfcc6e6ce1f94a00978bd38e7e46977b
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Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

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