Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish

Abstract Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity...

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Autores principales:	Sivakoti Sangabathuni, Raghavendra Vasudeva Murthy, Preeti Madhukar Chaudhary, Balamurugan Subramani, Suraj Toraskar, Raghavendra Kikkeri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cfcd20362534415a80e739574ecc11e6
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spelling	oai:doaj.org-article:cfcd20362534415a80e739574ecc11e62021-12-02T12:30:11ZMapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish10.1038/s41598-017-03350-32045-2322https://doaj.org/article/cfcd20362534415a80e739574ecc11e62017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03350-3https://doaj.org/toc/2045-2322Abstract Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity and the synthetic challenges in glycans synthesis, the cost of the high order in vivo models and large amount of sample consumptions limited the effort to translate the glyco-nanomaterials into clinical applications. In this regards, several promising simple animal models for preliminary, quick analysis of the nanomaterials activities has been proposed. Herein, we have studied a systematic evaluation of the toxicity, biodistribution of fluorescently tagged PEG and mannose-capped gold nanoparticles (AuNPs) of three different shapes (sphere, rod, and star) in the adult zebrafish model, which could accelerate and provide preliminary results for further experiments in the higher order animal system. ICP-MS analysis and confocal images of various zebrafish organs revealed that rod-AuNPs exhibited the fast uptake. While, star-AuNPs displayed prolong sequestration, demonstrating its potential therapeutic efficacy in drug delivery.Sivakoti SangabathuniRaghavendra Vasudeva MurthyPreeti Madhukar ChaudharyBalamurugan SubramaniSuraj ToraskarRaghavendra KikkeriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sivakoti Sangabathuni Raghavendra Vasudeva Murthy Preeti Madhukar Chaudhary Balamurugan Subramani Suraj Toraskar Raghavendra Kikkeri Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
description	Abstract Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity and the synthetic challenges in glycans synthesis, the cost of the high order in vivo models and large amount of sample consumptions limited the effort to translate the glyco-nanomaterials into clinical applications. In this regards, several promising simple animal models for preliminary, quick analysis of the nanomaterials activities has been proposed. Herein, we have studied a systematic evaluation of the toxicity, biodistribution of fluorescently tagged PEG and mannose-capped gold nanoparticles (AuNPs) of three different shapes (sphere, rod, and star) in the adult zebrafish model, which could accelerate and provide preliminary results for further experiments in the higher order animal system. ICP-MS analysis and confocal images of various zebrafish organs revealed that rod-AuNPs exhibited the fast uptake. While, star-AuNPs displayed prolong sequestration, demonstrating its potential therapeutic efficacy in drug delivery.
format	article
author	Sivakoti Sangabathuni Raghavendra Vasudeva Murthy Preeti Madhukar Chaudhary Balamurugan Subramani Suraj Toraskar Raghavendra Kikkeri
author_facet	Sivakoti Sangabathuni Raghavendra Vasudeva Murthy Preeti Madhukar Chaudhary Balamurugan Subramani Suraj Toraskar Raghavendra Kikkeri
author_sort	Sivakoti Sangabathuni
title	Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
title_short	Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
title_full	Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
title_fullStr	Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
title_full_unstemmed	Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish
title_sort	mapping the glyco-gold nanoparticles of different shapes toxicity, biodistribution and sequestration in adult zebrafish
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cfcd20362534415a80e739574ecc11e6
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Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish

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