DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA

Objective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas. Study Design: Cross sectional, comparative study. Place and Duration of Study: Study was conducted at department of Histopathology, A...

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Autores principales:	Sammeen Salim, Muhammad Asif, Rabia Ahmed, Hafeez Ud Din, Muhammad Tahir Khadim, Gazala Sadaf
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	cdx2 ck7 ck20 mcrc satb2 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.3034 https://doaj.org/article/cfce15e25f2f4cbc8bfe7aa048114b5e
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spelling	oai:doaj.org-article:cfce15e25f2f4cbc8bfe7aa048114b5e2021-12-02T15:12:58ZDIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMAhttps://doi.org/10.51253/pafmj.v71iSuppl-1.30340030-96482411-8842https://doaj.org/article/cfce15e25f2f4cbc8bfe7aa048114b5e2021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3034https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas. Study Design: Cross sectional, comparative study. Place and Duration of Study: Study was conducted at department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi from January 2019 to June 2019. Materials and Methods: Already diagnosed 68 cases of metastatic carcinoma of various origins with unknown primary were retrieved from tumour registry. Paraffin embedded blocks were taken and a panel of Immunohistochemistry was applied which includes CK7, CK20,CDX2 and SATB2. Positivity of SATB2 alone, and combination of SATB2 with CK 7,CK20 and CDX2 was evaluated. Results: Out of 68 metastatic adenocarcinoma cases 28(41%) had positive SATB2 expression and 38 (56%) were negative. All the positive SATB2 cases had 100 % (28/28) expression with CDX2, 93% (26/28) of the cases had expression with CK20 and 21% (6/28) of the cases showed expression of CK7. The sensitivity of SATB2 alone was 100% in metastatic colorectal carcinoma as compared to CK20 and CDX2. The sensitivity of SATB2 in combination with CDX2 (100%) and CK20 (93%)in comparison to the double combination of CK20 and CDX2(93 %). The sensitivity of SATB2 and CK20 combination was 93%, which was equal to CK20 and CDX2 combination. Conclusions: Our results show that SATB2 is a sensitive marker in the IHC panel for cases with suspected metastasis from colorectal region.Sammeen SalimMuhammad AsifRabia AhmedHafeez Ud DinMuhammad Tahir KhadimGazala SadafArmy Medical College Rawalpindiarticlecdx2ck7ck20mcrcsatb2MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 32-36 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cdx2 ck7 ck20 mcrc satb2 Medicine R Medicine (General) R5-920
spellingShingle	cdx2 ck7 ck20 mcrc satb2 Medicine R Medicine (General) R5-920 Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
description	Objective: The purpose of this study was to evaluate the diagnostic utility of SATB2 in detecting CRC origin for patients presenting with metastatic carcinomas. Study Design: Cross sectional, comparative study. Place and Duration of Study: Study was conducted at department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi from January 2019 to June 2019. Materials and Methods: Already diagnosed 68 cases of metastatic carcinoma of various origins with unknown primary were retrieved from tumour registry. Paraffin embedded blocks were taken and a panel of Immunohistochemistry was applied which includes CK7, CK20,CDX2 and SATB2. Positivity of SATB2 alone, and combination of SATB2 with CK 7,CK20 and CDX2 was evaluated. Results: Out of 68 metastatic adenocarcinoma cases 28(41%) had positive SATB2 expression and 38 (56%) were negative. All the positive SATB2 cases had 100 % (28/28) expression with CDX2, 93% (26/28) of the cases had expression with CK20 and 21% (6/28) of the cases showed expression of CK7. The sensitivity of SATB2 alone was 100% in metastatic colorectal carcinoma as compared to CK20 and CDX2. The sensitivity of SATB2 in combination with CDX2 (100%) and CK20 (93%)in comparison to the double combination of CK20 and CDX2(93 %). The sensitivity of SATB2 and CK20 combination was 93%, which was equal to CK20 and CDX2 combination. Conclusions: Our results show that SATB2 is a sensitive marker in the IHC panel for cases with suspected metastasis from colorectal region.
format	article
author	Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf
author_facet	Sammeen Salim Muhammad Asif Rabia Ahmed Hafeez Ud Din Muhammad Tahir Khadim Gazala Sadaf
author_sort	Sammeen Salim
title	DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
title_short	DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
title_full	DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
title_fullStr	DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
title_full_unstemmed	DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA
title_sort	diagnostic utility of satb2 in metastatic colorectal carcinoma
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.3034 https://doaj.org/article/cfce15e25f2f4cbc8bfe7aa048114b5e
work_keys_str_mv	AT sammeensalim diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma AT muhammadasif diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma AT rabiaahmed diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma AT hafeezuddin diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma AT muhammadtahirkhadim diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma AT gazalasadaf diagnosticutilityofsatb2inmetastaticcolorectalcarcinoma
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DIAGNOSTIC UTILITY OF SATB2 IN METASTATIC COLORECTAL CARCINOMA

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