Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

Abstract Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the analgesic activity of brimonidine. Method...

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Autores principales:	Chen Bin, Wang Xiaohui, Shi Mengrou, Li Xin, Zhang Ting, Gao Ping
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Brimonidine tartrate Adrenergic alpha-2 receptor agonists General anesthesia Lethal dose 50 Effective dose 50 Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/cfd17b14d75d4b80a29846ae55d4eb14
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spelling	oai:doaj.org-article:cfd17b14d75d4b80a29846ae55d4eb142021-12-05T12:07:57ZPreliminary evaluation of the efficacy and safety of brimonidine for general anesthesia10.1186/s12871-021-01516-11471-2253https://doaj.org/article/cfd17b14d75d4b80a29846ae55d4eb142021-12-01T00:00:00Zhttps://doi.org/10.1186/s12871-021-01516-1https://doaj.org/toc/1471-2253Abstract Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the analgesic activity of brimonidine. Methods The median effective dose (ED50) and lethal dose (LD50) of intraperitoneally injected brimonidine were determined in hypnotized mice. In addition, the LD50 of intravenously injected brimonidine, and ED50 of intravenously, intramuscularly, and intrarectally injected brimonidine in hypnotized rabbits were determined. Finally, the synergistic anesthetic effect of brimonidine and chloral hydrate was evaluated in rabbits. Results Intraperitoneal injection of 10 mg/kg brimonidine enhanced the hypnotic effect of a threshold dose of pentobarbital. Intraperitoneally injected brimonidine produced dose-related analgesic effects in mice. The ED50 of intraperitoneally administered brimonidine in hypnotized mice was 75.7 mg/kg and the LD50 was 379 mg/kg. ED50 values of intravenous, intramuscular, and intrarectal brimonidine for hypnosis in rabbits were 5.2 mg/kg, 8.8 mg/kg, and 8.7 mg/kg, respectively; the LD50 of intravenous brimonidine was 146 mg/kg. Combined intravenous administration of 0.6 mg/kg brimonidine and 0.03 g/kg chloral hydrate had a synergistic anesthetic effect. Conclusions Brimonidine elicited hypnotic and analgesic effects after systemic administration and exhibited safety. Moreover, brimonidine enhanced the effects of other types of narcotics when combined.Chen BinWang XiaohuiShi MengrouLi XinZhang TingGao PingBMCarticleBrimonidine tartrateAdrenergic alpha-2 receptor agonistsGeneral anesthesiaLethal dose 50Effective dose 50AnesthesiologyRD78.3-87.3ENBMC Anesthesiology, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brimonidine tartrate Adrenergic alpha-2 receptor agonists General anesthesia Lethal dose 50 Effective dose 50 Anesthesiology RD78.3-87.3
spellingShingle	Brimonidine tartrate Adrenergic alpha-2 receptor agonists General anesthesia Lethal dose 50 Effective dose 50 Anesthesiology RD78.3-87.3 Chen Bin Wang Xiaohui Shi Mengrou Li Xin Zhang Ting Gao Ping Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
description	Abstract Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the analgesic activity of brimonidine. Methods The median effective dose (ED50) and lethal dose (LD50) of intraperitoneally injected brimonidine were determined in hypnotized mice. In addition, the LD50 of intravenously injected brimonidine, and ED50 of intravenously, intramuscularly, and intrarectally injected brimonidine in hypnotized rabbits were determined. Finally, the synergistic anesthetic effect of brimonidine and chloral hydrate was evaluated in rabbits. Results Intraperitoneal injection of 10 mg/kg brimonidine enhanced the hypnotic effect of a threshold dose of pentobarbital. Intraperitoneally injected brimonidine produced dose-related analgesic effects in mice. The ED50 of intraperitoneally administered brimonidine in hypnotized mice was 75.7 mg/kg and the LD50 was 379 mg/kg. ED50 values of intravenous, intramuscular, and intrarectal brimonidine for hypnosis in rabbits were 5.2 mg/kg, 8.8 mg/kg, and 8.7 mg/kg, respectively; the LD50 of intravenous brimonidine was 146 mg/kg. Combined intravenous administration of 0.6 mg/kg brimonidine and 0.03 g/kg chloral hydrate had a synergistic anesthetic effect. Conclusions Brimonidine elicited hypnotic and analgesic effects after systemic administration and exhibited safety. Moreover, brimonidine enhanced the effects of other types of narcotics when combined.
format	article
author	Chen Bin Wang Xiaohui Shi Mengrou Li Xin Zhang Ting Gao Ping
author_facet	Chen Bin Wang Xiaohui Shi Mengrou Li Xin Zhang Ting Gao Ping
author_sort	Chen Bin
title	Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
title_short	Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
title_full	Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
title_fullStr	Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
title_full_unstemmed	Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
title_sort	preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cfd17b14d75d4b80a29846ae55d4eb14
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Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia

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