Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species

The discovery of new antibiotics to overcome the growing resistance problem as well as the discovery of new natural, safe antioxidants to combat oxidative stress are still urgently needed. Medicinal plants are known to produce potential therapeutic substances which are more biologically selective th...

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Autores principales:	Marlin Megalestin Raunsai, Kartika Dyah Palupi, Ahmad Fathoni, Andria Agusta
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	antibacterial, antioxidant, medicinal plants, phenolic content, halmahera island Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/cfd4aa8a4ccf414880e40461d365732e
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spelling	oai:doaj.org-article:cfd4aa8a4ccf414880e40461d365732e2021-11-15T06:08:46ZBioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species2338-94272338-948610.22146/ijp.1774https://doaj.org/article/cfd4aa8a4ccf414880e40461d365732e2021-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1774https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486The discovery of new antibiotics to overcome the growing resistance problem as well as the discovery of new natural, safe antioxidants to combat oxidative stress are still urgently needed. Medicinal plants are known to produce potential therapeutic substances which are more biologically selective than synthetic compounds. Therefore, we explored the bioactivities of 35 ethanolic extracts from 24 underexplored plant species collected in Halmahera, to find potential sources for antibacterial and antioxidant agents. Dried plant parts were extracted using ethanol 96%. Thin layer chromatography-direct-bioautography (TLC-DB) and minimum inhibitory concentration (MIC) determination were used to evaluate the antibacterial effect. Antioxidant activity was determined against DPPH using TLC-DB and microdilution assay. Total phenolic content (TPC) was determined using Folin-Ciocalteu’s method. The ethanolic extracts exhibited moderate to weak antibacterial activity against Escherichia coli and Staphylococcus aureus. However, the leaf extract of Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica as well as the stem bark extract of Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissima displayed very strong antioxidant activities against DPPH with AAI values between 4.60 to 13.42. A strong correlation between TPC and antioxidant activity with r = 0.8712 was observed. Despite the moderate to weak antibacterial activity, eight underexplored plant species exhibit strong antioxidant activities. A high correlation between TPC and antioxidant activity indicating a prominent role of phenolic compounds in the plants’ antioxidant properties. These findings indicate that collected plants from Halmahera are potential to be studied and developed further as the potential sources for novel antioxidants.Marlin Megalestin RaunsaiKartika Dyah PalupiAhmad FathoniAndria AgustaUniversitas Gadjah Madaarticleantibacterial, antioxidant, medicinal plants, phenolic content, halmahera islandPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 376-384 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibacterial, antioxidant, medicinal plants, phenolic content, halmahera island Pharmacy and materia medica RS1-441
spellingShingle	antibacterial, antioxidant, medicinal plants, phenolic content, halmahera island Pharmacy and materia medica RS1-441 Marlin Megalestin Raunsai Kartika Dyah Palupi Ahmad Fathoni Andria Agusta Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
description	The discovery of new antibiotics to overcome the growing resistance problem as well as the discovery of new natural, safe antioxidants to combat oxidative stress are still urgently needed. Medicinal plants are known to produce potential therapeutic substances which are more biologically selective than synthetic compounds. Therefore, we explored the bioactivities of 35 ethanolic extracts from 24 underexplored plant species collected in Halmahera, to find potential sources for antibacterial and antioxidant agents. Dried plant parts were extracted using ethanol 96%. Thin layer chromatography-direct-bioautography (TLC-DB) and minimum inhibitory concentration (MIC) determination were used to evaluate the antibacterial effect. Antioxidant activity was determined against DPPH using TLC-DB and microdilution assay. Total phenolic content (TPC) was determined using Folin-Ciocalteu’s method. The ethanolic extracts exhibited moderate to weak antibacterial activity against Escherichia coli and Staphylococcus aureus. However, the leaf extract of Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica as well as the stem bark extract of Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissima displayed very strong antioxidant activities against DPPH with AAI values between 4.60 to 13.42. A strong correlation between TPC and antioxidant activity with r = 0.8712 was observed. Despite the moderate to weak antibacterial activity, eight underexplored plant species exhibit strong antioxidant activities. A high correlation between TPC and antioxidant activity indicating a prominent role of phenolic compounds in the plants’ antioxidant properties. These findings indicate that collected plants from Halmahera are potential to be studied and developed further as the potential sources for novel antioxidants.
format	article
author	Marlin Megalestin Raunsai Kartika Dyah Palupi Ahmad Fathoni Andria Agusta
author_facet	Marlin Megalestin Raunsai Kartika Dyah Palupi Ahmad Fathoni Andria Agusta
author_sort	Marlin Megalestin Raunsai
title	Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
title_short	Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
title_full	Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
title_fullStr	Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
title_full_unstemmed	Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species
title_sort	bioactivities of plant extracts collected in halmahera, indonesia: a bioprospection study of underexplored plant species
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/cfd4aa8a4ccf414880e40461d365732e
work_keys_str_mv	AT marlinmegalestinraunsai bioactivitiesofplantextractscollectedinhalmaheraindonesiaabioprospectionstudyofunderexploredplantspecies AT kartikadyahpalupi bioactivitiesofplantextractscollectedinhalmaheraindonesiaabioprospectionstudyofunderexploredplantspecies AT ahmadfathoni bioactivitiesofplantextractscollectedinhalmaheraindonesiaabioprospectionstudyofunderexploredplantspecies AT andriaagusta bioactivitiesofplantextractscollectedinhalmaheraindonesiaabioprospectionstudyofunderexploredplantspecies
_version_	1718428583393755136

Bioactivities of plant extracts collected in Halmahera, Indonesia: A bioprospection study of underexplored plant species

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