Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics

Summary: Human neuroimaging studies have shown that, during cognitive processing, the brain undergoes dynamic transitions between multiple, frequency-tuned states of activity. Although different states may emerge from distinct sources of neural activity, it remains unclear whether single-area neuron...

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Autores principales:	Piergiorgio Salvan, Alberto Lazari, Diego Vidaurre, Francesca Mandino, Heidi Johansen-Berg, Joanes Grandjean
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	requency modulation dynamic brain networks optogenetics-fMRI hidden Markov modeling Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cfd6b62dab5f4bfa9ff42af2336798d0
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spelling	oai:doaj.org-article:cfd6b62dab5f4bfa9ff42af2336798d02021-11-04T04:29:49ZFrequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics2211-124710.1016/j.celrep.2021.109954https://doaj.org/article/cfd6b62dab5f4bfa9ff42af2336798d02021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014315https://doaj.org/toc/2211-1247Summary: Human neuroimaging studies have shown that, during cognitive processing, the brain undergoes dynamic transitions between multiple, frequency-tuned states of activity. Although different states may emerge from distinct sources of neural activity, it remains unclear whether single-area neuronal spiking can also drive multiple dynamic states. In mice, we ask whether frequency modulation of the entorhinal cortex activity causes dynamic states to emerge and whether these states respond to distinct stimulation frequencies. Using hidden Markov modeling, we perform unsupervised detection of transient states in mouse brain-wide fMRI fluctuations induced via optogenetic frequency modulation of excitatory neurons. We unveil the existence of multiple, frequency-dependent dynamic states, invisible through standard static fMRI analyses. These states are linked to different anatomical circuits and disrupted in a frequency-dependent fashion in a transgenic model of cognitive disease directly related to entorhinal cortex dysfunction. These findings provide cross-scale insight into basic neuronal mechanisms that may underpin flexibility in brain-wide dynamics.Piergiorgio SalvanAlberto LazariDiego VidaurreFrancesca MandinoHeidi Johansen-BergJoanes GrandjeanElsevierarticlerequency modulationdynamic brain networksoptogenetics-fMRIhidden Markov modelingBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109954- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	requency modulation dynamic brain networks optogenetics-fMRI hidden Markov modeling Biology (General) QH301-705.5
spellingShingle	requency modulation dynamic brain networks optogenetics-fMRI hidden Markov modeling Biology (General) QH301-705.5 Piergiorgio Salvan Alberto Lazari Diego Vidaurre Francesca Mandino Heidi Johansen-Berg Joanes Grandjean Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
description	Summary: Human neuroimaging studies have shown that, during cognitive processing, the brain undergoes dynamic transitions between multiple, frequency-tuned states of activity. Although different states may emerge from distinct sources of neural activity, it remains unclear whether single-area neuronal spiking can also drive multiple dynamic states. In mice, we ask whether frequency modulation of the entorhinal cortex activity causes dynamic states to emerge and whether these states respond to distinct stimulation frequencies. Using hidden Markov modeling, we perform unsupervised detection of transient states in mouse brain-wide fMRI fluctuations induced via optogenetic frequency modulation of excitatory neurons. We unveil the existence of multiple, frequency-dependent dynamic states, invisible through standard static fMRI analyses. These states are linked to different anatomical circuits and disrupted in a frequency-dependent fashion in a transgenic model of cognitive disease directly related to entorhinal cortex dysfunction. These findings provide cross-scale insight into basic neuronal mechanisms that may underpin flexibility in brain-wide dynamics.
format	article
author	Piergiorgio Salvan Alberto Lazari Diego Vidaurre Francesca Mandino Heidi Johansen-Berg Joanes Grandjean
author_facet	Piergiorgio Salvan Alberto Lazari Diego Vidaurre Francesca Mandino Heidi Johansen-Berg Joanes Grandjean
author_sort	Piergiorgio Salvan
title	Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
title_short	Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
title_full	Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
title_fullStr	Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
title_full_unstemmed	Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
title_sort	frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cfd6b62dab5f4bfa9ff42af2336798d0
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Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics

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