Treatment of refractory complex partial seizures: role of vigabatrin
Elizabeth J Waterhouse, Kimberly N Mims, Soundarya N GowdaDepartment of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, USAAbstract: Vigabatrin (VGB) is an antiepileptic drug that was designed to inhibit GABA-transaminase, and increase levels of γ-amino-bu...
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Dove Medical Press
2009
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oai:doaj.org-article:cfda930b54f04f13a515c3ef16fe78202021-12-02T02:52:53ZTreatment of refractory complex partial seizures: role of vigabatrin1176-63281178-2021https://doaj.org/article/cfda930b54f04f13a515c3ef16fe78202009-10-01T00:00:00Zhttp://www.dovepress.com/treatment-of-refractory-complex-partial-seizures-role-of-vigabatrin-a3612https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Elizabeth J Waterhouse, Kimberly N Mims, Soundarya N GowdaDepartment of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, USAAbstract: Vigabatrin (VGB) is an antiepileptic drug that was designed to inhibit GABA-transaminase, and increase levels of γ-amino-butyric acid (GABA), a major inhibitory neurotransmitter in the brain. VGB has demonstrated efficacy as an adjunctive antiepileptic drug for refractory complex partial seizures (CPS) and for infantile spasms (IS). This review focuses on its use for complex partial seizures. Although VGB is well tolerated, there have been significant safety concerns about intramyelinic edema and visual field defects. VGB is associated with a risk of developing bilateral concentric visual field defects. Therefore, the use of VGB for complex partial seizures should be limited to those patients with seizures refractory to other treatments. Patients must have baseline and follow-up monitoring of visual fields, early assessment of its efficacy, and ongoing evaluation of the benefits and risks of VGB therapy.Keywords: vigabatrin, epilepsy, complex partial seizures, review Elizabeth J WaterhouseKimberly N MimsSoundarya N GowdaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 505-515 (2009) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Elizabeth J Waterhouse Kimberly N Mims Soundarya N Gowda Treatment of refractory complex partial seizures: role of vigabatrin |
| description |
Elizabeth J Waterhouse, Kimberly N Mims, Soundarya N GowdaDepartment of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, USAAbstract: Vigabatrin (VGB) is an antiepileptic drug that was designed to inhibit GABA-transaminase, and increase levels of γ-amino-butyric acid (GABA), a major inhibitory neurotransmitter in the brain. VGB has demonstrated efficacy as an adjunctive antiepileptic drug for refractory complex partial seizures (CPS) and for infantile spasms (IS). This review focuses on its use for complex partial seizures. Although VGB is well tolerated, there have been significant safety concerns about intramyelinic edema and visual field defects. VGB is associated with a risk of developing bilateral concentric visual field defects. Therefore, the use of VGB for complex partial seizures should be limited to those patients with seizures refractory to other treatments. Patients must have baseline and follow-up monitoring of visual fields, early assessment of its efficacy, and ongoing evaluation of the benefits and risks of VGB therapy.Keywords: vigabatrin, epilepsy, complex partial seizures, review |
| format |
article |
| author |
Elizabeth J Waterhouse Kimberly N Mims Soundarya N Gowda |
| author_facet |
Elizabeth J Waterhouse Kimberly N Mims Soundarya N Gowda |
| author_sort |
Elizabeth J Waterhouse |
| title |
Treatment of refractory complex partial seizures: role of vigabatrin |
| title_short |
Treatment of refractory complex partial seizures: role of vigabatrin |
| title_full |
Treatment of refractory complex partial seizures: role of vigabatrin |
| title_fullStr |
Treatment of refractory complex partial seizures: role of vigabatrin |
| title_full_unstemmed |
Treatment of refractory complex partial seizures: role of vigabatrin |
| title_sort |
treatment of refractory complex partial seizures: role of vigabatrin |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/cfda930b54f04f13a515c3ef16fe7820 |
| work_keys_str_mv |
AT elizabethjwaterhouse treatmentofrefractorycomplexpartialseizuresroleofvigabatrin AT kimberlynmims treatmentofrefractorycomplexpartialseizuresroleofvigabatrin AT soundaryangowda treatmentofrefractorycomplexpartialseizuresroleofvigabatrin |
| _version_ |
1718402127386116096 |