Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis

Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis

Abstract The extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in p...

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Autores principales: Claudio Luchini, Achim Fleischmann, Joost L. Boormans, Matteo Fassan, Alessia Nottegar, Paola Lucato, Brendon Stubbs, Marco Solmi, Antonio Porcaro, Nicola Veronese, Matteo Brunelli, Aldo Scarpa, Liang Cheng
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cfe08d291c0246718e6ae43622d9e75c
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spelling oai:doaj.org-article:cfe08d291c0246718e6ae43622d9e75c2021-12-02T12:30:34ZExtranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis10.1038/s41598-017-02577-42045-2322https://doaj.org/article/cfe08d291c0246718e6ae43622d9e75c2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02577-4https://doaj.org/toc/2045-2322Abstract The extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in prostate cancer is still unclear. We aimed to clarify it, performing the first meta-analysis on this issue, comparing prognostic parameters in surgically treated, node-positive prostate cancer patients with (ENE+) vs. without (ENE−) ENE. Data were summarized using risk ratios (RRs) for number of deaths/recurrences and hazard ratios (HRs), with 95% confidence intervals (CI), for the time-dependent risk related to ENE positivity. Six studies followed-up 1,113 patients with N1 prostate cancer (658 ENE+ vs. 455 ENE−) for a median of 83 months. The presence of ENE was associated with a significantly higher risk of biochemical recurrence (RR = 1.15; 95%CI: 1.03–1.28; I2 = 0%; HR = 1.40, 95%CI: 1.12–1.74; I2 = 0%) and “global” (biochemical recurrence and distant metastasis) recurrence (RR = 1.15; 95%CI: 1.04–1.28; I2 = 0%; HR = 1.41, 95%CI: 1.14–1.74; I2 = 0%). ENE emerged as a potential prognostic moderator, earmarking a subgroup of patients at higher risk of recurrence. It may be considered for the prognostic stratification of metastatic patients. New possible therapeutic approaches may explore more in depth this prognostic parameter.Claudio LuchiniAchim FleischmannJoost L. BoormansMatteo FassanAlessia NottegarPaola LucatoBrendon StubbsMarco SolmiAntonio PorcaroNicola VeroneseMatteo BrunelliAldo ScarpaLiang ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Claudio Luchini
Achim Fleischmann
Joost L. Boormans
Matteo Fassan
Alessia Nottegar
Paola Lucato
Brendon Stubbs
Marco Solmi
Antonio Porcaro
Nicola Veronese
Matteo Brunelli
Aldo Scarpa
Liang Cheng
Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
description Abstract The extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in prostate cancer is still unclear. We aimed to clarify it, performing the first meta-analysis on this issue, comparing prognostic parameters in surgically treated, node-positive prostate cancer patients with (ENE+) vs. without (ENE−) ENE. Data were summarized using risk ratios (RRs) for number of deaths/recurrences and hazard ratios (HRs), with 95% confidence intervals (CI), for the time-dependent risk related to ENE positivity. Six studies followed-up 1,113 patients with N1 prostate cancer (658 ENE+ vs. 455 ENE−) for a median of 83 months. The presence of ENE was associated with a significantly higher risk of biochemical recurrence (RR = 1.15; 95%CI: 1.03–1.28; I2 = 0%; HR = 1.40, 95%CI: 1.12–1.74; I2 = 0%) and “global” (biochemical recurrence and distant metastasis) recurrence (RR = 1.15; 95%CI: 1.04–1.28; I2 = 0%; HR = 1.41, 95%CI: 1.14–1.74; I2 = 0%). ENE emerged as a potential prognostic moderator, earmarking a subgroup of patients at higher risk of recurrence. It may be considered for the prognostic stratification of metastatic patients. New possible therapeutic approaches may explore more in depth this prognostic parameter.
format article
author Claudio Luchini
Achim Fleischmann
Joost L. Boormans
Matteo Fassan
Alessia Nottegar
Paola Lucato
Brendon Stubbs
Marco Solmi
Antonio Porcaro
Nicola Veronese
Matteo Brunelli
Aldo Scarpa
Liang Cheng
author_facet Claudio Luchini
Achim Fleischmann
Joost L. Boormans
Matteo Fassan
Alessia Nottegar
Paola Lucato
Brendon Stubbs
Marco Solmi
Antonio Porcaro
Nicola Veronese
Matteo Brunelli
Aldo Scarpa
Liang Cheng
author_sort Claudio Luchini
title Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
title_short Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
title_full Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
title_fullStr Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
title_full_unstemmed Extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
title_sort extranodal extension of lymph node metastasis influences recurrence in prostate cancer: a systematic review and meta-analysis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cfe08d291c0246718e6ae43622d9e75c
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