Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.

The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL....

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Autores principales:	Zheng Liang, Arjan Diepstra, Chuanhui Xu, Gustaaf van Imhoff, Wouter Plattel, Anke Van Den Berg, Lydia Visser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cfe12edfe5d440e9afd9a17092a166ba
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spelling	oai:doaj.org-article:cfe12edfe5d440e9afd9a17092a166ba2021-11-18T08:35:16ZInsulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.1932-620310.1371/journal.pone.0087474https://doaj.org/article/cfe12edfe5d440e9afd9a17092a166ba2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489919/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p = .029 and PFS 77%, p = .047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines.Zheng LiangArjan DiepstraChuanhui XuGustaaf van ImhoffWouter PlattelAnke Van Den BergLydia VisserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87474 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng Liang Arjan Diepstra Chuanhui Xu Gustaaf van Imhoff Wouter Plattel Anke Van Den Berg Lydia Visser Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
description	The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p = .029 and PFS 77%, p = .047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines.
format	article
author	Zheng Liang Arjan Diepstra Chuanhui Xu Gustaaf van Imhoff Wouter Plattel Anke Van Den Berg Lydia Visser
author_facet	Zheng Liang Arjan Diepstra Chuanhui Xu Gustaaf van Imhoff Wouter Plattel Anke Van Den Berg Lydia Visser
author_sort	Zheng Liang
title	Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
title_short	Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
title_full	Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
title_fullStr	Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
title_full_unstemmed	Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
title_sort	insulin-like growth factor 1 receptor is a prognostic factor in classical hodgkin lymphoma.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cfe12edfe5d440e9afd9a17092a166ba
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Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.

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