Global Warming Will Bring New Fungal Diseases for Mammals

ABSTRACT Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV...

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Autores principales:	Monica A. Garcia-Solache, Arturo Casadevall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2010
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cfe47c2223124d2b8135493fb8491026
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spelling	oai:doaj.org-article:cfe47c2223124d2b8135493fb84910262021-11-15T15:38:14ZGlobal Warming Will Bring New Fungal Diseases for Mammals10.1128/mBio.00061-102150-7511https://doaj.org/article/cfe47c2223124d2b8135493fb84910262010-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00061-10https://doaj.org/toc/2150-7511ABSTRACT Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.Monica A. Garcia-SolacheArturo CasadevallAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 1, Iss 1 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Monica A. Garcia-Solache Arturo Casadevall Global Warming Will Bring New Fungal Diseases for Mammals
description	ABSTRACT Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.
format	article
author	Monica A. Garcia-Solache Arturo Casadevall
author_facet	Monica A. Garcia-Solache Arturo Casadevall
author_sort	Monica A. Garcia-Solache
title	Global Warming Will Bring New Fungal Diseases for Mammals
title_short	Global Warming Will Bring New Fungal Diseases for Mammals
title_full	Global Warming Will Bring New Fungal Diseases for Mammals
title_fullStr	Global Warming Will Bring New Fungal Diseases for Mammals
title_full_unstemmed	Global Warming Will Bring New Fungal Diseases for Mammals
title_sort	global warming will bring new fungal diseases for mammals
publisher	American Society for Microbiology
publishDate	2010
url	https://doaj.org/article/cfe47c2223124d2b8135493fb8491026
work_keys_str_mv	AT monicaagarciasolache globalwarmingwillbringnewfungaldiseasesformammals AT arturocasadevall globalwarmingwillbringnewfungaldiseasesformammals
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Global Warming Will Bring New Fungal Diseases for Mammals

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