Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

Abstract Introduction Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in...

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Autores principales:	Tingting Liu, Yuju Cao, Changxu Han, Feimeng An, Tiantian Wang, Menghu Sun, Chao Ma, Qiumei Dong, Jianzhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Steroid-induced osteonecrosis of the femoral head MIR17HG MIR155HG Single-nucleotide polymorphism Case–control study Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/cfe619c099374d3dbdfa626281957325
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spelling	oai:doaj.org-article:cfe619c099374d3dbdfa6262819573252021-11-21T12:29:54ZAssociation of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China10.1186/s13018-021-02669-y1749-799Xhttps://doaj.org/article/cfe619c099374d3dbdfa6262819573252021-11-01T00:00:00Zhttps://doi.org/10.1186/s13018-021-02669-yhttps://doaj.org/toc/1749-799XAbstract Introduction Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China. Methods A total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH. Results In the codominant model, patients with the MIR17HG SNPs (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039); in the recessive model, patients with the MIR17HG SNP (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). In the MIR17HG SNP (rs75267932), patients with different genotypes had different levels of triglyceride (TG). The MIR155HG SNPs (rs77699734, rs1893650, and rs34904192) showed differences in triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels in patients with different genotypes. Conclusion Our results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.Tingting LiuYuju CaoChangxu HanFeimeng AnTiantian WangMenghu SunChao MaQiumei DongJianzhong WangBMCarticleSteroid-induced osteonecrosis of the femoral headMIR17HGMIR155HGSingle-nucleotide polymorphismCase–control studyOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJournal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Steroid-induced osteonecrosis of the femoral head MIR17HG MIR155HG Single-nucleotide polymorphism Case–control study Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	Steroid-induced osteonecrosis of the femoral head MIR17HG MIR155HG Single-nucleotide polymorphism Case–control study Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Tingting Liu Yuju Cao Changxu Han Feimeng An Tiantian Wang Menghu Sun Chao Ma Qiumei Dong Jianzhong Wang Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
description	Abstract Introduction Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China. Methods A total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH. Results In the codominant model, patients with the MIR17HG SNPs (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039); in the recessive model, patients with the MIR17HG SNP (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). In the MIR17HG SNP (rs75267932), patients with different genotypes had different levels of triglyceride (TG). The MIR155HG SNPs (rs77699734, rs1893650, and rs34904192) showed differences in triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels in patients with different genotypes. Conclusion Our results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.
format	article
author	Tingting Liu Yuju Cao Changxu Han Feimeng An Tiantian Wang Menghu Sun Chao Ma Qiumei Dong Jianzhong Wang
author_facet	Tingting Liu Yuju Cao Changxu Han Feimeng An Tiantian Wang Menghu Sun Chao Ma Qiumei Dong Jianzhong Wang
author_sort	Tingting Liu
title	Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
title_short	Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
title_full	Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
title_fullStr	Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
title_full_unstemmed	Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China
title_sort	association of mir17hg and mir155hg gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern china
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cfe619c099374d3dbdfa626281957325
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Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

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