Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome

Sicca syndrome, which is typical for Sjögren’s syndrome (SS), is relatively often comorbid with other autoimmune diseases. The current classification criteria for SS published in 2016 include only anti-SSA (anti-Ro) autoantibody, while the latest literature proposes that anti-Ro60/anti-Ro52 autoanti...

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Autores principales:	Arkadiusz Koszarny, Maria Majdan
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	anti-ssa antibody anti-ro52 antibody anti-ro60 antibody primary sjögren’s syndrome. Medicine R
Acceso en línea:	https://doaj.org/article/cfe995d2e3c24eceb1018b53b812caed
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spelling	oai:doaj.org-article:cfe995d2e3c24eceb1018b53b812caed2021-12-02T17:18:54ZSicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome0034-62332084-983410.5114/reum.2021.108653https://doaj.org/article/cfe995d2e3c24eceb1018b53b812caed2021-08-01T00:00:00Zhttps://www.termedia.pl/Sicca-syndrome-in-the-same-family-the-importance-of-anti-Ro60-anti-Ro52-and-anti-La-antibody-profiling-in-Sjogren-s-syndrome,18,44992,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Sicca syndrome, which is typical for Sjögren’s syndrome (SS), is relatively often comorbid with other autoimmune diseases. The current classification criteria for SS published in 2016 include only anti-SSA (anti-Ro) autoantibody, while the latest literature proposes that anti-Ro60/anti-Ro52 autoantibody profiles should be used instead, as these two types of antibodies correlate with specific clinical symptoms and laboratory test findings. The paper presents the case of a 41-year-old woman suffering from primary Sjögren’s syndrome (pSS) and her three daughters, who were under observation for rheumatic disorders due to sicca symptoms, especially pSS, as well as a discussion on separate determination of anti-Ro60 and anti-Ro52 autoantibodies based on current literature in the PubMed database. When testing with antinuclear antibodies, the Ro60+Ro52+La+ autoantibody profile most closely matches for pSS. Further research is needed to find marker antibodies for SS and quantification methods.Arkadiusz KoszarnyMaria MajdanTermedia Publishing Housearticleanti-ssa antibody anti-ro52 antibody anti-ro60 antibody primary sjögren’s syndrome.MedicineRENRheumatology, Vol 59, Iss 4, Pp 260-264 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-ssa antibody anti-ro52 antibody anti-ro60 antibody primary sjögren’s syndrome. Medicine R
spellingShingle	anti-ssa antibody anti-ro52 antibody anti-ro60 antibody primary sjögren’s syndrome. Medicine R Arkadiusz Koszarny Maria Majdan Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
description	Sicca syndrome, which is typical for Sjögren’s syndrome (SS), is relatively often comorbid with other autoimmune diseases. The current classification criteria for SS published in 2016 include only anti-SSA (anti-Ro) autoantibody, while the latest literature proposes that anti-Ro60/anti-Ro52 autoantibody profiles should be used instead, as these two types of antibodies correlate with specific clinical symptoms and laboratory test findings. The paper presents the case of a 41-year-old woman suffering from primary Sjögren’s syndrome (pSS) and her three daughters, who were under observation for rheumatic disorders due to sicca symptoms, especially pSS, as well as a discussion on separate determination of anti-Ro60 and anti-Ro52 autoantibodies based on current literature in the PubMed database. When testing with antinuclear antibodies, the Ro60+Ro52+La+ autoantibody profile most closely matches for pSS. Further research is needed to find marker antibodies for SS and quantification methods.
format	article
author	Arkadiusz Koszarny Maria Majdan
author_facet	Arkadiusz Koszarny Maria Majdan
author_sort	Arkadiusz Koszarny
title	Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
title_short	Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
title_full	Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
title_fullStr	Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
title_full_unstemmed	Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome
title_sort	sicca syndrome in the same family – the importance of anti-ro60, anti-ro52 and anti-la antibody profiling in sjögren’s syndrome
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/cfe995d2e3c24eceb1018b53b812caed
work_keys_str_mv	AT arkadiuszkoszarny siccasyndromeinthesamefamilytheimportanceofantiro60antiro52andantilaantibodyprofilinginsjogrenssyndrome AT mariamajdan siccasyndromeinthesamefamilytheimportanceofantiro60antiro52andantilaantibodyprofilinginsjogrenssyndrome
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Sicca syndrome in the same family – the importance of anti-Ro60, anti-Ro52 and anti-La antibody profiling in Sjögren’s syndrome

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