Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients

Objective. Thyroid hormones play an important role in the development and maturation of the central nervous symptom and their failure in the prenatal period leading to an irreversible brain damage. Their effect on the brain of adult, however, has not been fully studied. With the discovery of neuroge...

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Autores principales:	Bilous Iryna I., Pavlovych Larysa L., Kamyshnyi Aleksandr M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	neurogenesis mrna autoimmune thyroiditis hypothyroidism Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/cfeb31b8ca54426cbb5afc9fdda176b0
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spelling	oai:doaj.org-article:cfeb31b8ca54426cbb5afc9fdda176b02021-12-02T16:40:25ZPrimary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients1336-032910.2478/enr-2021-0002https://doaj.org/article/cfeb31b8ca54426cbb5afc9fdda176b02021-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0002https://doaj.org/toc/1336-0329Objective. Thyroid hormones play an important role in the development and maturation of the central nervous symptom and their failure in the prenatal period leading to an irreversible brain damage. Their effect on the brain of adult, however, has not been fully studied. With the discovery of neurogenesis in the adult brain, many recent studies have been focused on the understanding the basic mechanisms controlling this process. Many neurogenesis regulatory genes are not only transcribed but also translated into the blood cells. The goal of our study was to analyze the transcriptional activity of neurogenesis regulatory genes in peripheral blood cells in patients with thyroid pathology.Bilous Iryna I.Pavlovych Larysa L.Kamyshnyi Aleksandr M.Sciendoarticleneurogenesismrnaautoimmune thyroiditishypothyroidismDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 1, Pp 5-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurogenesis mrna autoimmune thyroiditis hypothyroidism Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	neurogenesis mrna autoimmune thyroiditis hypothyroidism Diseases of the endocrine glands. Clinical endocrinology RC648-665 Bilous Iryna I. Pavlovych Larysa L. Kamyshnyi Aleksandr M. Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
description	Objective. Thyroid hormones play an important role in the development and maturation of the central nervous symptom and their failure in the prenatal period leading to an irreversible brain damage. Their effect on the brain of adult, however, has not been fully studied. With the discovery of neurogenesis in the adult brain, many recent studies have been focused on the understanding the basic mechanisms controlling this process. Many neurogenesis regulatory genes are not only transcribed but also translated into the blood cells. The goal of our study was to analyze the transcriptional activity of neurogenesis regulatory genes in peripheral blood cells in patients with thyroid pathology.
format	article
author	Bilous Iryna I. Pavlovych Larysa L. Kamyshnyi Aleksandr M.
author_facet	Bilous Iryna I. Pavlovych Larysa L. Kamyshnyi Aleksandr M.
author_sort	Bilous Iryna I.
title	Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
title_short	Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
title_full	Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
title_fullStr	Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
title_full_unstemmed	Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
title_sort	primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/cfeb31b8ca54426cbb5afc9fdda176b0
work_keys_str_mv	AT bilousirynai primaryhypothyroidismandautoimmunethyroiditisalterthetranscriptionalactivityofgenesregulatingneurogenesisinthebloodofpatients AT pavlovychlarysal primaryhypothyroidismandautoimmunethyroiditisalterthetranscriptionalactivityofgenesregulatingneurogenesisinthebloodofpatients AT kamyshnyialeksandrm primaryhypothyroidismandautoimmunethyroiditisalterthetranscriptionalactivityofgenesregulatingneurogenesisinthebloodofpatients
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Primary hypothyroidism and autoimmune thyroiditis alter the transcriptional activity of genes regulating neurogenesis in the blood of patients

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