Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial bl...

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Autores principales:	Jeffrey T. Kroetsch, Andrew S. Levy, Hangjun Zhang, Roozbeh Aschar-Sobbi, Darcy Lidington, Stefan Offermanns, Sergei A. Nedospasov, Peter H. Backx, Scott P. Heximer, Steffen-Sebastian Bolz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cfecfa36235d47528943452ab436b052
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spelling	oai:doaj.org-article:cfecfa36235d47528943452ab436b0522021-12-02T14:40:37ZConstitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure10.1038/ncomms148052041-1723https://doaj.org/article/cfecfa36235d47528943452ab436b0522017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14805https://doaj.org/toc/2041-1723TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.Jeffrey T. KroetschAndrew S. LevyHangjun ZhangRoozbeh Aschar-SobbiDarcy LidingtonStefan OffermannsSergei A. NedospasovPeter H. BackxScott P. HeximerSteffen-Sebastian BolzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey T. Kroetsch Andrew S. Levy Hangjun Zhang Roozbeh Aschar-Sobbi Darcy Lidington Stefan Offermanns Sergei A. Nedospasov Peter H. Backx Scott P. Heximer Steffen-Sebastian Bolz Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
description	TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.
format	article
author	Jeffrey T. Kroetsch Andrew S. Levy Hangjun Zhang Roozbeh Aschar-Sobbi Darcy Lidington Stefan Offermanns Sergei A. Nedospasov Peter H. Backx Scott P. Heximer Steffen-Sebastian Bolz
author_facet	Jeffrey T. Kroetsch Andrew S. Levy Hangjun Zhang Roozbeh Aschar-Sobbi Darcy Lidington Stefan Offermanns Sergei A. Nedospasov Peter H. Backx Scott P. Heximer Steffen-Sebastian Bolz
author_sort	Jeffrey T. Kroetsch
title	Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
title_short	Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
title_full	Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
title_fullStr	Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
title_full_unstemmed	Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
title_sort	constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cfecfa36235d47528943452ab436b052
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Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

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