Interspecies Jumping of Bat Coronaviruses

In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and c...

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Autores principales:	Antonio C. P. Wong, Susanna K. P. Lau, Patrick C. Y. Woo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	interspecies jumping bat coronavirus outbreak epidemic pandemic Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cfee53650ab7498689774e8c1d088a60
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spelling	oai:doaj.org-article:cfee53650ab7498689774e8c1d088a602021-11-25T19:13:11ZInterspecies Jumping of Bat Coronaviruses10.3390/v131121881999-4915https://doaj.org/article/cfee53650ab7498689774e8c1d088a602021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2188https://doaj.org/toc/1999-4915In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and civets and genomic studies have confirmed bat-to-civet-to-human transmission. The MERS epidemic that emerged in 2012 had a ~35% mortality, with dromedaries as the reservoir. Although CoVs with the same genome organization (e.g., <i>Tylonycteris</i> BatCoV HKU4 and <i>Pipistrellus</i> BatCoV HKU5) were also detected in bats, there is still a phylogenetic gap between these bat CoVs and MERS-CoV. In 2016, 10 years after the discovery of <i>Rhinolophus</i> BatCoV HKU2 in Chinese horseshoe bats, fatal swine disease outbreaks caused by this virus were reported in southern China. In late 2019, an outbreak of pneumonia emerged in Wuhan, China, and rapidly spread globally, leading to >4,000,000 fatalities so far. Although the genome of SARS-CoV-2 is highly similar to that of SARS-CoV, patient zero and the original source of the pandemic are still unknown. To protect humans from future public health threats, measures should be taken to monitor and reduce the chance of interspecies jumping events, either occurring naturally or through recombineering experiments.Antonio C. P. WongSusanna K. P. LauPatrick C. Y. WooMDPI AGarticleinterspecies jumpingbatcoronavirusoutbreakepidemicpandemicMicrobiologyQR1-502ENViruses, Vol 13, Iss 2188, p 2188 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interspecies jumping bat coronavirus outbreak epidemic pandemic Microbiology QR1-502
spellingShingle	interspecies jumping bat coronavirus outbreak epidemic pandemic Microbiology QR1-502 Antonio C. P. Wong Susanna K. P. Lau Patrick C. Y. Woo Interspecies Jumping of Bat Coronaviruses
description	In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and civets and genomic studies have confirmed bat-to-civet-to-human transmission. The MERS epidemic that emerged in 2012 had a ~35% mortality, with dromedaries as the reservoir. Although CoVs with the same genome organization (e.g., <i>Tylonycteris</i> BatCoV HKU4 and <i>Pipistrellus</i> BatCoV HKU5) were also detected in bats, there is still a phylogenetic gap between these bat CoVs and MERS-CoV. In 2016, 10 years after the discovery of <i>Rhinolophus</i> BatCoV HKU2 in Chinese horseshoe bats, fatal swine disease outbreaks caused by this virus were reported in southern China. In late 2019, an outbreak of pneumonia emerged in Wuhan, China, and rapidly spread globally, leading to >4,000,000 fatalities so far. Although the genome of SARS-CoV-2 is highly similar to that of SARS-CoV, patient zero and the original source of the pandemic are still unknown. To protect humans from future public health threats, measures should be taken to monitor and reduce the chance of interspecies jumping events, either occurring naturally or through recombineering experiments.
format	article
author	Antonio C. P. Wong Susanna K. P. Lau Patrick C. Y. Woo
author_facet	Antonio C. P. Wong Susanna K. P. Lau Patrick C. Y. Woo
author_sort	Antonio C. P. Wong
title	Interspecies Jumping of Bat Coronaviruses
title_short	Interspecies Jumping of Bat Coronaviruses
title_full	Interspecies Jumping of Bat Coronaviruses
title_fullStr	Interspecies Jumping of Bat Coronaviruses
title_full_unstemmed	Interspecies Jumping of Bat Coronaviruses
title_sort	interspecies jumping of bat coronaviruses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cfee53650ab7498689774e8c1d088a60
work_keys_str_mv	AT antoniocpwong interspeciesjumpingofbatcoronaviruses AT susannakplau interspeciesjumpingofbatcoronaviruses AT patrickcywoo interspeciesjumpingofbatcoronaviruses
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Interspecies Jumping of Bat Coronaviruses

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