Incretins in the Therapy of Diabetic Kidney Disease

Diabetic kidney disease is a microvascular complication that occurs in patients with diabetes. It is strongly associated with increased risk of kidney replacement therapy and all-cause mortality. Incretins are peptide hormones derived from the gastrointestinal tract, that besides causing enhancement...

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Autores principales:	Agnieszka Przezak, Weronika Bielka, Andrzej Pawlik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes diabetic kidney disease incretins therapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cff00ea746964b33a16960d1ced5ad61
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id	oai:doaj.org-article:cff00ea746964b33a16960d1ced5ad61
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spelling	oai:doaj.org-article:cff00ea746964b33a16960d1ced5ad612021-11-25T17:55:19ZIncretins in the Therapy of Diabetic Kidney Disease10.3390/ijms2222123121422-00671661-6596https://doaj.org/article/cff00ea746964b33a16960d1ced5ad612021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12312https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Diabetic kidney disease is a microvascular complication that occurs in patients with diabetes. It is strongly associated with increased risk of kidney replacement therapy and all-cause mortality. Incretins are peptide hormones derived from the gastrointestinal tract, that besides causing enhancement of insulin secretion after oral glucose intake, participate in many other metabolic processes. Antidiabetic drug classes, such as dipeptidyl peptidase 4 inhibitors and glucagon-like peptide receptor agonists, which way of action is based on incretins facility, not only show glucose-lowering properties but also have nephroprotective functions. The aim of this article is to present the latest information about incretin-based therapy and its influence on diabetic kidney disease appearance and progression, point its potential mechanisms of kidney protection and focus on future therapeutic possibilities bound with these two antidiabetic drug classes.Agnieszka PrzezakWeronika BielkaAndrzej PawlikMDPI AGarticlediabetesdiabetic kidney diseaseincretinstherapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12312, p 12312 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes diabetic kidney disease incretins therapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	diabetes diabetic kidney disease incretins therapy Biology (General) QH301-705.5 Chemistry QD1-999 Agnieszka Przezak Weronika Bielka Andrzej Pawlik Incretins in the Therapy of Diabetic Kidney Disease
description	Diabetic kidney disease is a microvascular complication that occurs in patients with diabetes. It is strongly associated with increased risk of kidney replacement therapy and all-cause mortality. Incretins are peptide hormones derived from the gastrointestinal tract, that besides causing enhancement of insulin secretion after oral glucose intake, participate in many other metabolic processes. Antidiabetic drug classes, such as dipeptidyl peptidase 4 inhibitors and glucagon-like peptide receptor agonists, which way of action is based on incretins facility, not only show glucose-lowering properties but also have nephroprotective functions. The aim of this article is to present the latest information about incretin-based therapy and its influence on diabetic kidney disease appearance and progression, point its potential mechanisms of kidney protection and focus on future therapeutic possibilities bound with these two antidiabetic drug classes.
format	article
author	Agnieszka Przezak Weronika Bielka Andrzej Pawlik
author_facet	Agnieszka Przezak Weronika Bielka Andrzej Pawlik
author_sort	Agnieszka Przezak
title	Incretins in the Therapy of Diabetic Kidney Disease
title_short	Incretins in the Therapy of Diabetic Kidney Disease
title_full	Incretins in the Therapy of Diabetic Kidney Disease
title_fullStr	Incretins in the Therapy of Diabetic Kidney Disease
title_full_unstemmed	Incretins in the Therapy of Diabetic Kidney Disease
title_sort	incretins in the therapy of diabetic kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cff00ea746964b33a16960d1ced5ad61
work_keys_str_mv	AT agnieszkaprzezak incretinsinthetherapyofdiabetickidneydisease AT weronikabielka incretinsinthetherapyofdiabetickidneydisease AT andrzejpawlik incretinsinthetherapyofdiabetickidneydisease
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Incretins in the Therapy of Diabetic Kidney Disease

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