Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits

Karem H Alzoubi,1 Zuhair Bani Ismail,2 Mohamed K AL-Essa,3 Osama Y Alshogran,1 Reem F Abutayeh,4 Nareman Abu-Baker5 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Veterinary Clinical Sciences, Faculty of Veterinary Me...

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Autores principales:	Alzoubi KH, Ismail ZB, AL-Essa MK, Alshogran OY, Abutayeh RF, Abu-Baker N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	D-ribose single-dose pharmacokinetics rabbits oral intravenous Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cff4392fb21748159e4dedaef333d313
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spelling	oai:doaj.org-article:cff4392fb21748159e4dedaef333d3132021-12-02T01:38:18ZPharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits1179-1438https://doaj.org/article/cff4392fb21748159e4dedaef333d3132018-06-01T00:00:00Zhttps://www.dovepress.com/pharmacokinetic-evaluation-of-d-ribose-after-oral-and-intravenous-admi-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Karem H Alzoubi,1 Zuhair Bani Ismail,2 Mohamed K AL-Essa,3 Osama Y Alshogran,1 Reem F Abutayeh,4 Nareman Abu-Baker5 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Physiology, Faculty of Medicine, University of Jordan, Amman, Jordan; 4Department of Medicinal Chemistry and Phytochemistry, Applied Science Private University, Amman, Jordan; 5Philadelphia Biomedical Products Development Center, Amman, Jordan Introduction: This study explored d-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits. Materials and methods: D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration–time data using Kinetica software. Results: The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUCtotal was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (Tmax=36–44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18–37.5%) recovered from urine. Conclusion: Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo. Keywords: D-ribose, single dose, pharmacokinetics, rabbits, oral, intravenousAlzoubi KHIsmail ZBAL-Essa MKAlshogran OYAbutayeh RFAbu-Baker NDove Medical PressarticleD-ribosesingle-dosepharmacokineticsrabbitsoralintravenousTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 10, Pp 73-78 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	D-ribose single-dose pharmacokinetics rabbits oral intravenous Therapeutics. Pharmacology RM1-950
spellingShingle	D-ribose single-dose pharmacokinetics rabbits oral intravenous Therapeutics. Pharmacology RM1-950 Alzoubi KH Ismail ZB AL-Essa MK Alshogran OY Abutayeh RF Abu-Baker N Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
description	Karem H Alzoubi,1 Zuhair Bani Ismail,2 Mohamed K AL-Essa,3 Osama Y Alshogran,1 Reem F Abutayeh,4 Nareman Abu-Baker5 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Physiology, Faculty of Medicine, University of Jordan, Amman, Jordan; 4Department of Medicinal Chemistry and Phytochemistry, Applied Science Private University, Amman, Jordan; 5Philadelphia Biomedical Products Development Center, Amman, Jordan Introduction: This study explored d-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits. Materials and methods: D-ribose was administered once as 420 mg/kg (N=4) or 840 mg/kg (N=6) dose intravenously, or as an oral dose of 420 mg/kg (N=3) or 840 mg/kg (N=3). Serum was obtained at various time points, up to 210 minutes after administration. Urine was also collected after IV administration. Pharmacokinetic parameters were determined from drug concentration–time data using Kinetica software. Results: The findings showed that D-ribose follows a dose-dependent kinetic profile. With doubling the IV dose, AUCtotal was significantly increased by threefold, while the clearance was decreased by 44%. The half-life was 1.7-fold longer at the higher dose. Similar nonsignificant trends were also observed at oral administration. D-ribose was rapidly absorbed (Tmax=36–44 minutes) and rapidly disappeared from plasma (within <140 minutes). Additionally, D-ribose was partially (18–37.5%) recovered from urine. Conclusion: Collectively, D-ribose showed a dose-dependent kinetic profile, where parameters change according to dosing levels. D-ribose clearance seems to follow first-order kinetics at low dose. Thereafter, elimination systems are saturated, and elimination continues in a fast manner. Urine recovery was partial, which could be attributed to the several metabolic pathways that pentose can undergo. Keywords: D-ribose, single dose, pharmacokinetics, rabbits, oral, intravenous
format	article
author	Alzoubi KH Ismail ZB AL-Essa MK Alshogran OY Abutayeh RF Abu-Baker N
author_facet	Alzoubi KH Ismail ZB AL-Essa MK Alshogran OY Abutayeh RF Abu-Baker N
author_sort	Alzoubi KH
title	Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
title_short	Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
title_full	Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
title_fullStr	Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
title_full_unstemmed	Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits
title_sort	pharmacokinetic evaluation of d-ribose after oral and intravenous administration to healthy rabbits
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cff4392fb21748159e4dedaef333d313
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Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits

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